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Hello Can you tell me please what enzymes do continuous glucose monitors use? I think the available are: GO = glucose oxidase GDH-PQQ = glucose dehydrogenase with pyrroloquinolinequinone GDH-NAD = glucose dehydrogenase with nicotinamide-adenine dinucleotide GDH-FAD = glucose dehydrogenase with...

Hello What is the size of the CGM? how wide and thick it is? Thanks!

Hello Does interstitial flud go out when I insert the needle from a CGM or Insulin Pump? I suppose that needle is very thin but would it make the interstitial fluid leak out? Thanks

So one LDL molecule which is 3million daltons is 3 x 1.6 x 10-18 grams, so one mole is that times 6x10^23 equals 28x10^5 grams or 3tonnes, exactly what I said.

Okay and what is the true LDL density then?

kiloDaltons is a molecular mass unit. 1Dalton = 1g/mol by definition. Here it says that LDL chylomicrons are 3million Daltons. https://en.wikipedia.org/wiki/Low-density_lipoprotein 386g/mol is the molecular weight of cholesterol itself, not of LDL

Hello! LDL has 3,000 kDa molecular weight which means that 1mol of it weighs 3 tonnes. When we say for a patient that LDL is 5mM we mean that they have 5mmol per 1L of their blood. However, 5mmol of LDL would weigh 15kg! What's wrong?

I highly doubt my doctor will know that.

No it's another one: http://sitn.hms.harvard.edu/flash/2019/using-chimeric-proteins-fight-type-ii-diabetes/ But still don't understand what they target exactly and how?

They made a chimeric one which evades immune system. But how exactly suppresses appetite by targeting hypothalamus? Is there an appetite centre or something?

Do we know which nerves?

But how?

Hello! What is the mechanism of action of Axokine? Thanks!

After a meal the insulin released results in 100-200pmol/L. This is very very tiny concentration. How can this activate all the cells in the body? Also how can insulin spread to the body almost immediately while glucose absorbed in blood takes 15min to raise glucose in the tissues?

After few minutes from a meal, insulin is secreted into blood. How can these molecules go to all the tissues within minutes and trigger glucose uptake in cells? How can insulin reach every region in the body within minutes? Also, gow can few micrograms of insukin released in blood act on every...

Okay I thought they had already solved the clotting challenge as we are implanting pacemakers and other devices without risk (not sure if you need to take blood thinners for life though).

Why continuous glucose monitors do not access blood? Why they work on interstitial fluid only and not capillary blood?

I have been trying to figure out what is the state of the art in this sector. That Glucowise thingy is "in development" for the last 5 years at least, since I came across it, it is like a scam. Are there any big companies interested in minimally invasive glucose monitoring without penetrating...

Hello Which companies work on non-invasive glucose monitoring? What is in the pipeline? Thanks!

I need a prescription immediately. Why pharmacists do not prescribe?