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That sounds very disheartening. I don't know what you do or what is right for you but i can only say what i have found works for me. I too am on metformin 750mg X2 slow release. I have been doing a 16/8 fast (which i built up to slowly over about a week, first 8/16, 10/14, 12/12, 14/10, 16/8 so...