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I have been a type 1 for nearly 40 years with pretty good control and now have kidney failure with eGFR of 14 ( on transplant list)but have noticeable wastage of thigh muscles now which I understand is diabetic neuropathy and my nephrologist blames the diabetes and diabetes doctor blames kidneys...

Am Type 1 and starting to find my control of insulin very poor after over 40 years of really good control and was wondering if one can build up a resistance to manufactured insulin after so many years All my searching on the net just keeps bringing up resistance to insulin as the onset of...