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Message: <blockquote data-quote="Oldvatr" data-source="post: 2615406" data-attributes="member: 196898">The incretin mimetics work by effectively jamming a crowbar into the beta cells in the pancreas, and switching them on for much longer than they would naturally.  Now there is an automatic mechanism in the beta cells that cause the insulin to switch off when glucose is below about 5 mmol/l so should not cause a hypo.  but in some people this mechanism is faulty.  You may be one of the unlucky ones that have a lower threshold.  It is to do with calcium and potassium levels in the blood, so maybe your potassium is out of whack?  Not sure if it going high or low is the culprit, but is a possibility.  The problem is that once the med is injected, then the effect lasts well past the half life for the med  which for the early incretins is around 11 hours.  compare this to the normal beta cell response to food which is much shorter (typ. one or two hours)  So any hypo will tend to last longer than expected.</blockquote>

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