Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2025 »
Home
Forums
Diabetes Discussion
Ask A Question
8 causes of diabetes
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="VictorVillalobos" data-source="post: 1311101" data-attributes="member: 353530"><p>Hi Guys, I am starting this new thread because some of you out there were discussing already to move forward from the simple paradigm of muscle insulin resistance, liver insulin resistance and insufficient insulin production.</p><p></p><p>Here is a more sophisticated model: the eight causes of diabetes. I would like to ask people here, especially those who seem to have nailed down their management of blood glucose,</p><p></p><p>a. Have you identified which problems you have behind your high blood glucose?</p><p>b. If so, how did you did it?</p><p>c. What was the solution you used?</p><p></p><p>The eight causes, as explained by Dr DeFronzo in the lecture he gave when obtaining the 2008 Banting memorial prize are:</p><p></p><p>1. Muscle insulin resistance</p><p>2. liver insulin resistance</p><p>3. B cell disfunctiona first phase insulin secretion and insufficient insulin secretion</p><p>4. Fat cell accelerated lipolysis</p><p>5. incretin deficiency/resistance in the intestine</p><p>6. Hyperglucagonemia or disfunction of the alpha cells in the pancreas</p><p>7. increased glucose reabsortion in the kidney</p><p>8. Dysfunctional Brain messaging (for example insulin resistance)</p><p></p><p>Here are two links to overview the model.</p><p>A short video: <a href="https://www.novomedlink.com/professional-education/clinical-education/the-ominous-octet-core-defects-in-type2-diabetes.html" target="_blank">https://www.novomedlink.com/professional-education/clinical-education/the-ominous-octet-core-defects-in-type2-diabetes.html</a></p><p>The paper:</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661582/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661582/</a></p><p></p><p>I just emailed to verify if he had major changes to this model from 2008. Will keep you posted.</p></blockquote><p></p>
[QUOTE="VictorVillalobos, post: 1311101, member: 353530"] Hi Guys, I am starting this new thread because some of you out there were discussing already to move forward from the simple paradigm of muscle insulin resistance, liver insulin resistance and insufficient insulin production. Here is a more sophisticated model: the eight causes of diabetes. I would like to ask people here, especially those who seem to have nailed down their management of blood glucose, a. Have you identified which problems you have behind your high blood glucose? b. If so, how did you did it? c. What was the solution you used? The eight causes, as explained by Dr DeFronzo in the lecture he gave when obtaining the 2008 Banting memorial prize are: 1. Muscle insulin resistance 2. liver insulin resistance 3. B cell disfunctiona first phase insulin secretion and insufficient insulin secretion 4. Fat cell accelerated lipolysis 5. incretin deficiency/resistance in the intestine 6. Hyperglucagonemia or disfunction of the alpha cells in the pancreas 7. increased glucose reabsortion in the kidney 8. Dysfunctional Brain messaging (for example insulin resistance) Here are two links to overview the model. A short video: [URL]https://www.novomedlink.com/professional-education/clinical-education/the-ominous-octet-core-defects-in-type2-diabetes.html[/URL] The paper: [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661582/[/URL] I just emailed to verify if he had major changes to this model from 2008. Will keep you posted. [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Ask A Question
8 causes of diabetes
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…
