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A better way to check ketones?
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<blockquote data-quote="MrMaggs" data-source="post: 1040883" data-attributes="member: 185561"><p>Thanks for this. I agree current urine ketone testing is inaccurate, a large part of which is due to the fact that (i) it tests different ketones from the ones that blood readers test (acetoacetate in urine vs BHB in blood), (ii) in DKA or adapted ketosis, the dominant ketone being excreted is BHB and not acetoacetate (roughly 9:1 ratio!!), (iii) the urine test strips require a fairly significant amount of ketones to react, so the more dilute your urine is the less the chance of a reading, and (iv) the strips provide a qualitative reading (broad range) and not a quantitative reading (accurate number). So yeah, they suck!</p><p></p><p>What we discovered is a way to test BHB in urine to give a quantitative reading, even very small traces that could not be picked up by a test strip (it uses a special microreactor, which can be installed in a handheld device - you hold a probe which is part of the device in your urine stream and it takes a sample, then tests and checks automatically). However, the issue of the fact that the ketones in urine (whether BHB or acetoacetate) are excess ketones still stands - so we are going to run a research trial on this in the next few months to get to the bottom of it. Will share the results when they come through!</p></blockquote><p></p>
[QUOTE="MrMaggs, post: 1040883, member: 185561"] Thanks for this. I agree current urine ketone testing is inaccurate, a large part of which is due to the fact that (i) it tests different ketones from the ones that blood readers test (acetoacetate in urine vs BHB in blood), (ii) in DKA or adapted ketosis, the dominant ketone being excreted is BHB and not acetoacetate (roughly 9:1 ratio!!), (iii) the urine test strips require a fairly significant amount of ketones to react, so the more dilute your urine is the less the chance of a reading, and (iv) the strips provide a qualitative reading (broad range) and not a quantitative reading (accurate number). So yeah, they suck! What we discovered is a way to test BHB in urine to give a quantitative reading, even very small traces that could not be picked up by a test strip (it uses a special microreactor, which can be installed in a handheld device - you hold a probe which is part of the device in your urine stream and it takes a sample, then tests and checks automatically). However, the issue of the fact that the ketones in urine (whether BHB or acetoacetate) are excess ketones still stands - so we are going to run a research trial on this in the next few months to get to the bottom of it. Will share the results when they come through! [/QUOTE]
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