A Puzzling Question I Have Not Yet To Find An Answer

[HICHAM_T2]

Hi

In fact, I have already asked this question before and I have no answer. I hope not to be bothered by the repetition of the question

Many members know that diabetes T2 is caused by cell resistance to insulin
Sometimes insulin production is many

My Question Is :
Why cells accept external insulin while not accepting internal natural insulin ?

Is there a difference between them in amino acids ?

 

[Bluetit1802]

Hi

In fact, I have already asked this question before and I have no answer. I hope not to be bothered by the repetition of the question

Many members know that diabetes T2 is caused by cell resistance to insulin

my question is
Why cells accept external insulin while not accepting internal natural insulin ?

Is there a difference between them in amino acids ?

If a person is injecting external insulin, and that person has insulin resistance, he will have to inject a lot more insulin to get the same effect as someone without insulin resistance. His cells will reject it, just as they do with natural insulin.

This is the same with someone not injecting insulin. When there is insulin resistance, the pancreas has to secrete much more insulin than is normal to clear the glucose out of the blood stream.

 

[Jaylee]

Hi @hichamgsm ,

In short. Exogenous insulin adds to the endogenous produced by the pancreas & increasing the chance of blood sugar being utilised by the cells.. (More keys to open the door!) it all does the same job..

 

[HICHAM_T2]

If a person is injecting external insulin, and that person has insulin resistance, he will have to inject a lot more insulin to get the same effect as someone without insulin resistance. His cells will reject it, just as they do with natural insulin.

This is the same with someone not injecting insulin. When there is insulin resistance, the pancreas has to secrete much more insulin than is normal to clear the glucose out of the blood stream.

But this means that this type will not benefit the use of insulin !!!

 

[Bluetit1802]

But this means that this type will not benefit the use of insulin !!!

No, not at all. The injected insulin does work, it just takes more of it. Just the same as you and I who don't need to inject insulin - if we have IR our pancreas has to produce a lot more insulin. This is what is bad for our health, likewise too much injected insulin.

 

[first14808]

But this means that this type will not benefit the use of insulin !!!

They will. The way I think of it is the pancreatic beta cells can only produce so much insulin. If there's insulin resistance, the body can't produce enough insulin on it's own to reduce blood glucose levels. Hence insulin injections to boost the amount in the blood. It may also be needed if there's damage to the pancrease, ie auto-immune problems meaning fewer beta cells, so falling insulin production.

 

[HICHAM_T2]

Hi @hichamgsm ,

In short. Exogenous insulin adds to the endogenous produced by the pancreas & increasing the chance of blood sugar being utilised by the cells.. (More keys to open the door!) it all does the same job..

Hi @Jaylee
Sorry for the inconvenience

Do you want to say that natural insulin needs external insulin to become effective ?

 

[Jaylee]

Sorry for the inconvenience

Do you want to say that natural insulin needs external insulin to become effective ?

No inconvenience at all, my friend.

Imagine trying to knock a bowling pin down with one ball? Then the increased chance of hitting the pin with more balls thrown at the same time...

 

[HICHAM_T2]

No inconvenience at all, my friend.

Imagine trying to knock a bowling pin down with one ball? Then the increased chance of hitting the pin with more balls thrown at the same time...

I understood what you meant thank you
But I personally think there is a defect in amino acids why not
Just guess I might be wrong