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Message: <blockquote data-quote="Sid Bonkers" data-source="post: 1414200" data-attributes="member: 19121">Metformin doesnt work instantly meal by meal like fast acting insulin does, metformin works over a 24 hour period and for best results should be taken twice a day, morning and evening with food ie with breakfast and an evening meal.I dont suppose it makes a huge difference you taking it three times a day but it may have a worse effect on your tummy if you take it without food..The food acts like a barrier and I found it best to take it during a meal ie after I had eaten a few mouthfuls of food I would take my tablet/s and then continue eating. That way I avoided any cramps, nausea and upset stomach.</blockquote>

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