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Type 2 Diabetes
Advice on Metformin
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<blockquote data-quote="desidiabulum" data-source="post: 1765790" data-attributes="member: 39515"><p>Sorry -- just a few tiny corrections: genetic testing does not always reveal precisely which gene is involved with MODY -- they are still identifying new ones (though it's definitely worth having the test done); gliclazide IS a sulphonylurea; there's no reason why MODY wouldn't be treated with metformin in combination with other drugs (some forms of MODY are especially sensitive to sulphonylureas but not all). Metformin is generally a safe drug -- though a few people are allergic to it and it does reduce B12 in the longer term. I stopped taking it because the side-effects of even the slow-release form made my life intolerable and exacerbated other conditions. I get by with gliclazide and carb count the usual way. Sulphonylureas may ultimately squeeze your pancreas dry, so if you can tolerate metformin and it is helping you keep your levels under control then it's worth sticking with it, I'd say. I would still see a diagnosis of MODY rather than T1 as an enormous plus</p></blockquote><p></p>
[QUOTE="desidiabulum, post: 1765790, member: 39515"] Sorry -- just a few tiny corrections: genetic testing does not always reveal precisely which gene is involved with MODY -- they are still identifying new ones (though it's definitely worth having the test done); gliclazide IS a sulphonylurea; there's no reason why MODY wouldn't be treated with metformin in combination with other drugs (some forms of MODY are especially sensitive to sulphonylureas but not all). Metformin is generally a safe drug -- though a few people are allergic to it and it does reduce B12 in the longer term. I stopped taking it because the side-effects of even the slow-release form made my life intolerable and exacerbated other conditions. I get by with gliclazide and carb count the usual way. Sulphonylureas may ultimately squeeze your pancreas dry, so if you can tolerate metformin and it is helping you keep your levels under control then it's worth sticking with it, I'd say. I would still see a diagnosis of MODY rather than T1 as an enormous plus [/QUOTE]
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