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Afrezza inhaled fast acting insulin
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<blockquote data-quote="brendan101" data-source="post: 1230104" data-attributes="member: 179417"><p>Hi There,</p><p></p><p>I see your concerns. Afrezza is not like any other insulin on the market. You need to forget about carb counting and exact dosages with Afrezza. A 4 unit of AFrezza is not the same as a 4 unit dose of injectable. There will come a time when the manufacturers will do away with insulin units on the packaging but it had to be there to show a comparison to what's available now. This was done as part of the trials in the USA and for regulatory reasons. Afrezza is a first phase insulin meaning that the insulin travels first from the lungs to the targett organ ie the liver and stops the release of glucose from there which does not happen to any significant extend with injectable insulin because most of it is floating around in the bloodsteam playing havoc on energy levels and BG control. Since the liver is not stopped from dumping out glucose at meal times for a diabetic person we generally go high after eating. This is why Afrezza can literally flatten BG profiles. It kicks in with ultra rapid acting pace after 12-15 minutes and clears the body within an hour meaning no risk of a hypo 2-3 hours after eating. I was really surprised when I first used it as I thought the liver would not respond as I have been an insulin dependant diabetic for 30 years. It did. I felt fantastic! </p><p></p><p>When I use Afrezza I normally take a 4 or 8 unit dose (8 unit dose if I am eating 30g CHO or more) and followup with a 4 unit dose if I need to 2 hours later. This has to do with the amount of carbs and the carb:fat ratio the latter can slow down absorption of glucose. I like to call it a blue dose (4) or green dose (8) with Afrezza. It mimics endogenous insulin. I was 100% more in range and no increase in hypos either. The irony of the whole thing was that I was not even trying too hard! It is definitely possible to control diabetes. The tools we have now have people in constant fear of hypos, coma, death or one of many life-changing crippling complications. Check out my good friend Sam Finta who is doing a great job of helping people with Afrezza. There is also plenty of Twitter users in the USA reporting amazing control with Afrezza, something that they never dreamed was possible until Afrezza came their way.</p><p><a href="http://afrezzauser.com/" target="_blank">http://afrezzauser.com/</a></p><p></p><p>I looked at all of this before starting to use Afrezza. Mannkind the manufacturers have released a titration pack recently t help people overcome these barriers to UNITS that they have had to fear and deal with for a long time. It's amazing how it does what it does but it solves a very difficult problem that plagues people on injectable analogue insulin. </p><p></p><p>Afrezza is not a cure and it does require input but I had control back and it was so so liberating. NICE are looking at it currently and the NHS are funding it for at least one patient in the UK on compassionate grounds at present.</p></blockquote><p></p>
[QUOTE="brendan101, post: 1230104, member: 179417"] Hi There, I see your concerns. Afrezza is not like any other insulin on the market. You need to forget about carb counting and exact dosages with Afrezza. A 4 unit of AFrezza is not the same as a 4 unit dose of injectable. There will come a time when the manufacturers will do away with insulin units on the packaging but it had to be there to show a comparison to what's available now. This was done as part of the trials in the USA and for regulatory reasons. Afrezza is a first phase insulin meaning that the insulin travels first from the lungs to the targett organ ie the liver and stops the release of glucose from there which does not happen to any significant extend with injectable insulin because most of it is floating around in the bloodsteam playing havoc on energy levels and BG control. Since the liver is not stopped from dumping out glucose at meal times for a diabetic person we generally go high after eating. This is why Afrezza can literally flatten BG profiles. It kicks in with ultra rapid acting pace after 12-15 minutes and clears the body within an hour meaning no risk of a hypo 2-3 hours after eating. I was really surprised when I first used it as I thought the liver would not respond as I have been an insulin dependant diabetic for 30 years. It did. I felt fantastic! When I use Afrezza I normally take a 4 or 8 unit dose (8 unit dose if I am eating 30g CHO or more) and followup with a 4 unit dose if I need to 2 hours later. This has to do with the amount of carbs and the carb:fat ratio the latter can slow down absorption of glucose. I like to call it a blue dose (4) or green dose (8) with Afrezza. It mimics endogenous insulin. I was 100% more in range and no increase in hypos either. The irony of the whole thing was that I was not even trying too hard! It is definitely possible to control diabetes. The tools we have now have people in constant fear of hypos, coma, death or one of many life-changing crippling complications. Check out my good friend Sam Finta who is doing a great job of helping people with Afrezza. There is also plenty of Twitter users in the USA reporting amazing control with Afrezza, something that they never dreamed was possible until Afrezza came their way. [URL]http://afrezzauser.com/[/URL] I looked at all of this before starting to use Afrezza. Mannkind the manufacturers have released a titration pack recently t help people overcome these barriers to UNITS that they have had to fear and deal with for a long time. It's amazing how it does what it does but it solves a very difficult problem that plagues people on injectable analogue insulin. Afrezza is not a cure and it does require input but I had control back and it was so so liberating. NICE are looking at it currently and the NHS are funding it for at least one patient in the UK on compassionate grounds at present. [/QUOTE]
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