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Afrezza inhaled fast acting insulin
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<blockquote data-quote="alaska" data-source="post: 802847" data-attributes="member: 14213"><p>A key point about Afrezza is that whilst its time to peak insulin level is very quick -see graph B</p><p><a href="http://images.rxlist.com/images/rxlist/afrezza2.gif" target="_blank">http://images.rxlist.com/images/rxlist/afrezza2.gif</a></p><p></p><p>Its action on blood glucose levels is not (the glucose infusion rate (GIR)) -see graph A in the .gif file in the link</p><p></p><p>Put simply, much of the insulin inhaled gets into your bloodstream within 15 minutes but it's actually not that much quicker to improve BG levels than injected insulin.</p><p></p><p>Note also that the area under the curve for Afrezza is much smaller, so you need to take a larger dose of Afrezza than you do of an injected dose. This is presumably the reason why Afrezza advise rounding the dose UP to the nearest block of 4 units. I'd be interested to see how glucose levels respond for larger doses of insulin (eg 16 units plus).</p><p></p><p>I gather this is one of the reasons why, in clinical trials, Afrezza users had, in real terms, inferior HbA1c results.</p></blockquote><p></p>
[QUOTE="alaska, post: 802847, member: 14213"] A key point about Afrezza is that whilst its time to peak insulin level is very quick -see graph B [URL]http://images.rxlist.com/images/rxlist/afrezza2.gif[/URL] Its action on blood glucose levels is not (the glucose infusion rate (GIR)) -see graph A in the .gif file in the link Put simply, much of the insulin inhaled gets into your bloodstream within 15 minutes but it's actually not that much quicker to improve BG levels than injected insulin. Note also that the area under the curve for Afrezza is much smaller, so you need to take a larger dose of Afrezza than you do of an injected dose. This is presumably the reason why Afrezza advise rounding the dose UP to the nearest block of 4 units. I'd be interested to see how glucose levels respond for larger doses of insulin (eg 16 units plus). I gather this is one of the reasons why, in clinical trials, Afrezza users had, in real terms, inferior HbA1c results. [/QUOTE]
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