Angry.....Perplexed...... dunno

Hi Shax

This doesn't answer your question very directly I'm afraid but it might be useful to read anyhow.

tudiabetes.org/profiles/blogs/a-practical-symlin-guide-for

It's about a drug called Amylin which can help to reduce post meal sugar level spiking.

It's prescribed in the US, but as far as I know is not prescribed in the UK.

Edmund

You should also take note of this which I posted about on January 6th in response to a question regarding Symlin (Pramlintide).

As far as we are aware this drug is not available in the UK. We know of no plans to licence it here. All the information about it is from the USA. Freely available on the net. As stated it appears to be for use in conjunction with Insulin so would be available to T1 and T2 alike.

There is a warning for this drug:
WARNING
SYMLIN is used with insulin and has been associated with an increased risk of insulin induced severe hypoglycemia, particularly in patients with type 1 diabetes. When severe hypoglycemia associated with SYMLIN use occurs, it is seen within 3 hours following a SYMLIN injection. If severe hypoglycemia occurs while operating a motor vehicle, heavy machinery, or while engaging in other high-risk activities, serious injuries may occur. Appropriate patient selection, careful patient instruction, and insulin dose adjustments are critical elements for reducing this risk.

Click to expand...

I'm not too surprised that they're now looking into whether type 2 treatments could also benefit type 1.

http://www.diabetes.co.uk/news/2011...help-those-with-type-1-diabetes-90975736.html

DPP-4s help to inhibit the release of glucagon.

Hi Shax
Before considering you are "insulin resistant" or trying any type-2 medications-Have you tried any other "type-1" treatments ie; other insulin types?
I often wonder why a logically-minded doctor wouldn't consider that if one medication isn't working, try another?? That would be the case in other circumstances eg; antibiotics, the contracecptive pill (re-side-effects), etc;
If Lantus was a true 24 hour basal profile, natural insulin, then the person or the diabetes management; diet, dose, etc; could be blamed. However Lantus is a synthetic analogue insulin, not natural and not perfect; many problems experienced by patients in recent years clearly show that it does not have 24 coverage for some people and certainly not a flat profile for others.
As for the "insulin resistance" theory, surely you'd have to be on insulin in the first place?? While Lantus and other analogues can accurately be referred to as "blood-sugar lowering drugs" they are not insulin. The difference between insulin and synthetically produced ones, can have a huge impact on people who suffer side-effects, even if we don't know exactly why. Similarly people can have excellent control on analogues while others have erratic and inconsistent swings, and changing insulins can solve both problems in both of the aforementioned cases.
Please consider changing your insulin, cause some things you said in your previous posts, eg the synacthen test, sound scarily similar to my experience.
Jus