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Another potential nail in LDL's coffin ?
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<blockquote data-quote="DaveKeto" data-source="post: 1675381" data-attributes="member: 410565"><p>Sorry, that is a poorly worded sentence. I should update it...</p><p></p><p>Basically, I'm saying reference ranges for low to high risk is probably different for those on a low carb diet over those on a high carb diet. A low carb diet has an appropriate reason to send out and traffick more VLDLs at any given time, given it is part of its core energy distribution. Whereas a high carb diet shouldn't be trafficking as many VLDLs given its primary energy is glucose/glycogen. Thus, it may well be a sign of trouble for the carb-centric diet at a certain RC level where it isn't for the low carber because it's routine.</p><p></p><p>Again, all of this comes back to the VLDLs themselves aren't the problem, it's the fact they are either (1) in a traffic jam (hyperinsulinemia/past fat threshold) or (2) higher quantities in order to fight disease (see Siobhan's upcoming piece). Either way, it can be a <em>reflection</em> of a broken system so long as one keeps the correct context in mind (how much VLDLs expected due to being fat-centric vs carb-centric).</p><p></p><p>I hope I articulated that a lot better.</p><p></p><p>tl:dr More VLDLs are appropriate on a fat-centric diet and may thus skew the RC ranges.</p></blockquote><p></p>
[QUOTE="DaveKeto, post: 1675381, member: 410565"] Sorry, that is a poorly worded sentence. I should update it... Basically, I'm saying reference ranges for low to high risk is probably different for those on a low carb diet over those on a high carb diet. A low carb diet has an appropriate reason to send out and traffick more VLDLs at any given time, given it is part of its core energy distribution. Whereas a high carb diet shouldn't be trafficking as many VLDLs given its primary energy is glucose/glycogen. Thus, it may well be a sign of trouble for the carb-centric diet at a certain RC level where it isn't for the low carber because it's routine. Again, all of this comes back to the VLDLs themselves aren't the problem, it's the fact they are either (1) in a traffic jam (hyperinsulinemia/past fat threshold) or (2) higher quantities in order to fight disease (see Siobhan's upcoming piece). Either way, it can be a [I]reflection[/I] of a broken system so long as one keeps the correct context in mind (how much VLDLs expected due to being fat-centric vs carb-centric). I hope I articulated that a lot better. tl:dr More VLDLs are appropriate on a fat-centric diet and may thus skew the RC ranges. [/QUOTE]
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