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Another potential nail in LDL's coffin ?
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<blockquote data-quote="DaveKeto" data-source="post: 1676061" data-attributes="member: 410565"><p>Yes -- Please fast at least 8 hours, preferably 12 before taking a lipid panel. When eating a meal, you WILL have fat packaged into chylomicrons as TG, which WILL increase your serum TG levels (and again, note that TG is part of what is used in the Friedewald calculation for LDL-C). This isn't speculative, it's simple molecular accounting. </p><p></p><p>The only question is how long it takes for the very last chylomicron to be cleared by the liver from the food you ate -- and there's disagreement in studies there. What I can tell you is that there's basically no disagreement that it will be cleared after 12 hours of fasting.</p><p></p><p>Moreover, there are many other non-lipid blood markers that can be impacted in the wake of a fed state. And note that the fed state length of time/process is highly varied by the meal and individual's metabolic health itself. This is why the new change in the guideline is so outrageous to me.</p></blockquote><p></p>
[QUOTE="DaveKeto, post: 1676061, member: 410565"] Yes -- Please fast at least 8 hours, preferably 12 before taking a lipid panel. When eating a meal, you WILL have fat packaged into chylomicrons as TG, which WILL increase your serum TG levels (and again, note that TG is part of what is used in the Friedewald calculation for LDL-C). This isn't speculative, it's simple molecular accounting. The only question is how long it takes for the very last chylomicron to be cleared by the liver from the food you ate -- and there's disagreement in studies there. What I can tell you is that there's basically no disagreement that it will be cleared after 12 hours of fasting. Moreover, there are many other non-lipid blood markers that can be impacted in the wake of a fed state. And note that the fed state length of time/process is highly varied by the meal and individual's metabolic health itself. This is why the new change in the guideline is so outrageous to me. [/QUOTE]
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Another potential nail in LDL's coffin ?
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