So for me, I follow the instructions for accuchek combo... obsessively when filling the cartridge, first I warm for 1hour out of the fridge (I think less air is soluble in the liquid after it warms) then, yes some cartridge finger nail flicking before connection and pushing the blue plunger up to remove air(push air back into the phial). Then very carefully connect, and after putting into pump, and starting the prime, I tap the base of the pump on a flat surface (or palm), until the bubbles come out and stop appearing.
This is from memory and I am not doing it now, so may have forgotten some steps, but this approach works for me and I don't get bubbles during use