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Message: <blockquote data-quote="SteveGladden" data-source="post: 1040443" data-attributes="member: 258812"><p>Not sure if this any help? I have been type 1 for 53 years and too have found that sensitivity has reduced, I have been on Metformin for about 4 years or so, it does work (reduce dosage of actrapid) but it's definitely not an exact science with me. I find that sensitivity through the day varies, morning particularly where at the moment I don't even give myself any Actrapid, but boost the Lantus dose. My advice for spiralling doses, would be just cut back, stop eating excessively try to manage high blood sugars by additional bolus (very small doses, for obvious reasons), once you have an idea about direction of travel of your sugars, work out your unit/carb ratio and remember that the whole thing is dynamic and subject to change. I have always struggled with trying to be on top of it, but hba1c's are good so that is good enough. Another helpful matter is one of exercise and keeping on top of weight, fats in the body will always make a difference to sensitivity.</p></blockquote><p></p>