Any Type 1 have experience with PPIs (Omeprazole)

@atomeye I'm aware I'm x posting here. I do not produce enough insulin, and I am insulin sensitive.
I take PPI's for peptic ulcer disease, plus I've had GERD issues in the past. I take the most powerful slow release PPI available, Dexlansoprazole 60mg. It has made no difference to my blood sugars. I have been on these particular PPI's for 3 months now. I have in the past taken Lansoprazole and Omeprazole. They work, but I do feel mildly nauseated on them, and the nausea is unrelated to eating.

Long term usage can upset the balance of bacteria in the gut leading to dysbiosis. In the long term there is a small risk of SIBO (Small Intestinal Bacterial Overgrowth) and Clostridiodes or C. difficile, which is a severe infection of the colon. I have taken them on and off for years after suffering from bleeding peptic ulcers with no issues.

The only other small possible issue, after long term usage, is Type 2 DM. Which would translate to a reduction in insulin sensitivity - insulin resistance for T1DM. This hasn't happened to me. I'm thinking that for someone on insulin therapy it may mean having to increase insulin dosing to compensate for the decreased insulin sensitivity. I must stress this has not happened to me. And PPI usage has not increased my C- Peptides which are low to normal. I hope that helps.

I have been taking PPI's for just shy of a year now. I'm currently on Lansoprazole although did trial Omeprazole but it did not agree with me and my epilepsy medication, they all relatively do the same thing anyway. I haven't noticed a difference in my diabetes control with them, I'm pretty insulin resistant anyway and was before I started taking them, whether it's made it any worse I'm not sure but my ratios haven't changed since taking them. I've had no adverse side effects from taking them, I get silent reflux and my dose has just been upped to twice a day 30mg each time due to my symptoms which is a relatively "high" dose. If anything they just help my reflux symptoms and don't affect me in any other way.

I've been taking omeprazole for about 9 months. (Was getting symptoms of either angina or heartburn and as I've now been put on low dose aspirin for aterioschlerosis they want me to stay on the omeprazole .) Hadn't noticed any symptoms at all from it but have recently had some gut issues so might have a discussion with my GP.... (Disclaimer, don't think the gut issues are caused by the omeprazole because I've had them occasionally for years and they do seem to be triggered by certain foods and (sob) drinks. And since I was put on a low dose beta blocker at the same time, it could just as well be that.)

atomeye said:

Thank you all for replying. I really appreciate it. I'm meeting with my GI next week to talk about some options. I tried Prilosec OTC a few weeks ago for a couple of days, but discontinued use. While it did help with my symptoms, it gave me lots of nausea and headaches. Will these side effects go away over time?

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I'm on Dexlansoprazole, a slow release PPI. DePrilosec or Omeprazole is a milder PPI and can be bought over the counter in the US. I too suffered nausea after taking a PPI. I was taking mine in the morning, but I switched to taking it just before my evening meal. It helped me a lot. I haven't noticed the nausea.