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Message: <blockquote data-quote="Melgar" data-source="post: 2764235" data-attributes="member: 520626">I read somewhere, and I'll dig the article out, that the genetic risk factor is lower in adults than it is for children and young adults, this relates to the DQ2/8 and DR3/4 genotypes. Children often having both types, therefore at greater risk (Interestingly I too have both DQ and DR types) The auto antibodies variation is greater in children, not just GADA , but also the production of IAA, ZnT8Ab and ICA autoantibodies.Adult onset T1 is more common than child onset, probably because of the age ranges involved - 20 years for children / young adults compared to 20 years upwards thus 20/80+ years. I just skimmed the surface of the biological factors. Then of course there are environmental factors as well.<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8546280/" target="_blank">https://pmc.ncbi.nlm.nih.gov/articles/PMC8546280/</a>Edited to add paper.</blockquote>

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