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Type 1 Diabetes
Are you sure its type 1 doc?
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<blockquote data-quote="AMBrennan" data-source="post: 340431" data-attributes="member: 37697"><p>With all due respect, but I cannot follow that line of thought at all. T2s tend to be insulin resistant and require a lot of insulin, so small doses would suggest that the T1 diagnosis is, in fact, correct. </p><p></p><p>As for the GAD test, I take it that you're not a statistician? The vast majority of people diagnosed with diabetes when they are in DKA are T1s (yes, exceptions do exist), so even with a negative GAD test I'd still bet on T1; I'd go as far as saying that this is probably the textbook illustration for Bayes theorem (GAD negative = positive for T2).</p><p></p><p>Personally, I am fairly happy to be T1; its onset is fast enough to be diagnosed before getting any complications and the finality of the diagnosis leaves one less vulnerable to snake oil salesmen that exploit desperate people e.g. looking to avoid having to to go on the dreaded insulin. </p><p>What's more, as I understand it we can more or less fix T1: The body produces no insulin, so you inject the amount you should be producing. T2 is more complicated, and the solution to "insulin not working properly" is just "use more insulin" (insulin secretagogue and insulin), which is hardly ideal - e.g. at the maximally tolerated dose of Metformin, liver glucogenesis is still <a href="http://diabetes.diabetesjournals.org/content/49/12/2063.full.pdf" target="_blank">above normal</a>... so you use more insulin to move the rest out of the bloodstream and store it as fat?</p></blockquote><p></p>
[QUOTE="AMBrennan, post: 340431, member: 37697"] With all due respect, but I cannot follow that line of thought at all. T2s tend to be insulin resistant and require a lot of insulin, so small doses would suggest that the T1 diagnosis is, in fact, correct. As for the GAD test, I take it that you're not a statistician? The vast majority of people diagnosed with diabetes when they are in DKA are T1s (yes, exceptions do exist), so even with a negative GAD test I'd still bet on T1; I'd go as far as saying that this is probably the textbook illustration for Bayes theorem (GAD negative = positive for T2). Personally, I am fairly happy to be T1; its onset is fast enough to be diagnosed before getting any complications and the finality of the diagnosis leaves one less vulnerable to snake oil salesmen that exploit desperate people e.g. looking to avoid having to to go on the dreaded insulin. What's more, as I understand it we can more or less fix T1: The body produces no insulin, so you inject the amount you should be producing. T2 is more complicated, and the solution to "insulin not working properly" is just "use more insulin" (insulin secretagogue and insulin), which is hardly ideal - e.g. at the maximally tolerated dose of Metformin, liver glucogenesis is still [url=http://diabetes.diabetesjournals.org/content/49/12/2063.full.pdf]above normal[/url]... so you use more insulin to move the rest out of the bloodstream and store it as fat? [/QUOTE]
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