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Article about SGLT2i, possible actions, possible effects on kidneys. Reviews please!
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<blockquote data-quote="LittleGreyCat" data-source="post: 2660223" data-attributes="member: 6467"><p><a href="https://www.nature.com/articles/s41371-021-00482-y" target="_blank">SGLTi and hypertension</a></p><p></p><p>This talks about hypertension, and the use of SGLT2i and low carbohydrate diets with relation to hypertension.</p><p>However a lot of the article talks about diabetes (often linked with hypertension) and the effects of hyperglycaemia.</p><p></p><p>It seems to say that SGLT2i can have a very similar effect to carbohydrate restriction, because both reduce the amount of glucose in the blood and encourage the use of ketones and other fats for energy.</p><p>Therefor why use drugs if low carbohydrate can give the same results without the side effects of drugs?</p><p>[Noting Dr David Unwin<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite6" alt=":cool:" title="Cool :cool:" loading="lazy" data-shortname=":cool:" /> as one of the authors.]</p><p></p><p>I've only read it once, but a couple of things struck me.</p><p></p><p>I think that it suggests that reducing the load on the kidneys by reducing the amount of glucose re-absorbed can improve kidney function.</p><p>I would appreciate a view on this.</p><p>I has assumed that using the kidneys to clear glucose would put an additional load on them.</p><p>I would be more than happy to be proved wrong.</p><p></p><p>It also says:</p><p>"So how can we get the drug-like outcomes, without financing or taking the drug? What is the right way to move forward when both can produce “mirror-like” results but they cannot therefore be combined? "</p><p>Is this poor wording for combining the two approaches provides no additional benefits, or is it suggesting that SGLT2i should not be combined with a restricted carbohydrate diet?</p><p>This could be a key issue.</p><p></p><p>Are there people here eating low carbohydrate and also taking SGLT2i drugs?</p><p></p><p>Reviews of this paper (especially on the points mentioned) would be very helpful, thanks.</p></blockquote><p></p>
[QUOTE="LittleGreyCat, post: 2660223, member: 6467"] [URL='https://www.nature.com/articles/s41371-021-00482-y']SGLTi and hypertension[/URL] This talks about hypertension, and the use of SGLT2i and low carbohydrate diets with relation to hypertension. However a lot of the article talks about diabetes (often linked with hypertension) and the effects of hyperglycaemia. It seems to say that SGLT2i can have a very similar effect to carbohydrate restriction, because both reduce the amount of glucose in the blood and encourage the use of ketones and other fats for energy. Therefor why use drugs if low carbohydrate can give the same results without the side effects of drugs? [Noting Dr David Unwin:cool: as one of the authors.] I've only read it once, but a couple of things struck me. I think that it suggests that reducing the load on the kidneys by reducing the amount of glucose re-absorbed can improve kidney function. I would appreciate a view on this. I has assumed that using the kidneys to clear glucose would put an additional load on them. I would be more than happy to be proved wrong. It also says: "So how can we get the drug-like outcomes, without financing or taking the drug? What is the right way to move forward when both can produce “mirror-like” results but they cannot therefore be combined? " Is this poor wording for combining the two approaches provides no additional benefits, or is it suggesting that SGLT2i should not be combined with a restricted carbohydrate diet? This could be a key issue. Are there people here eating low carbohydrate and also taking SGLT2i drugs? Reviews of this paper (especially on the points mentioned) would be very helpful, thanks. [/QUOTE]
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