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B12 And Metformin
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<blockquote data-quote="Alexandra100" data-source="post: 1842376" data-attributes="member: 429870"><p>This is from Jenny Ruhl's website : </p><p></p><p><span style="font-size: 12px"><strong>"Metformin May Deplete Vitamin B-12 and Folate</strong></span></p><p>Metformin has one more significant side effect. It may deplete Vitamin B-12 because it may alter the ability of the body to absorb vitamin B-12 from the gut. If this is the case, oral supplementation will not help. You would need to have Vitamin B-12 shots to address this deficiency. </p><p></p><p>Typically it takes about 10 years for low Vitamin B-12 levels to develop, but if you are already marginal for Vitamin B-12 or have other issues with your ability to absorb nutrients this might happen earlier. Your doctor should periodically test your Vitamin B-12 levels if you are taking Metformin.</p><p>Low vitamin B-12 causes a form of neuropathy that can be confused with diabetic neuropathy but which is something different. </p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14535967" target="_blank">Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.</a>Wulffele MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, Donker AJ, Stehouwer CD.<em>J Intern Med.</em> 2003 Nov;254(5):455-63."</p><p></p><p>You can read the whole of her article on Metformin here: <a href="http://www.phlaunt.com/diabetes/14045911.php" target="_blank">http://www.phlaunt.com/diabetes/14045911.php</a></p></blockquote><p></p>
[QUOTE="Alexandra100, post: 1842376, member: 429870"] This is from Jenny Ruhl's website : [SIZE=3][B]"Metformin May Deplete Vitamin B-12 and Folate[/B][/SIZE] Metformin has one more significant side effect. It may deplete Vitamin B-12 because it may alter the ability of the body to absorb vitamin B-12 from the gut. If this is the case, oral supplementation will not help. You would need to have Vitamin B-12 shots to address this deficiency. Typically it takes about 10 years for low Vitamin B-12 levels to develop, but if you are already marginal for Vitamin B-12 or have other issues with your ability to absorb nutrients this might happen earlier. Your doctor should periodically test your Vitamin B-12 levels if you are taking Metformin. Low vitamin B-12 causes a form of neuropathy that can be confused with diabetic neuropathy but which is something different. [URL='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14535967']Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.[/URL]Wulffele MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, Donker AJ, Stehouwer CD.[I]J Intern Med.[/I] 2003 Nov;254(5):455-63." You can read the whole of her article on Metformin here: [URL]http://www.phlaunt.com/diabetes/14045911.php[/URL] [/QUOTE]
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