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Message: <blockquote data-quote="sue_marie" data-source="post: 1847636" data-attributes="member: 48624">Thanks for your info Kitedoc but I still believe the possible link between metformin-B12-pernicious anaemia needs to be looked at more seriously.In the same section on Webmd you referred to, it says “The reason this [low B12] happens is often due to the lack of a <a href="https://www.webmd.com/digestive-disorders/picture-of-the-stomach" target="_blank">stomach</a> protein called “intrinsic factor” (IF). Your body can’t absorb vitamin B-12 without it.... Some medicines, like antacids or drugs that <a href="https://www.webmd.com/diabetes/type-2-diabetes-treatments" target="_blank">treat type 2 diabetes</a>, can make it harder for your body to absorb enough B-12.”As I have no other illness apart from T2 (and now PA <img class="smilie smilie--emoji" loading="lazy" alt="☹️" title="Frowning face    :frowning2:" src="https://cdn.jsdelivr.net/joypixels/assets/6.6/png/unicode/64/2639.png" data-shortname=":frowning2:" />), am not a vegetarian and there is no family history of PA, I assume that long term metformin could well be the reason my body’s intrinsic factor (IF) has been destroyed and consequently affected my B12 levels. Hence my concern that B12 should be routinely checked for metformin users.</blockquote>

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