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B12 And Metformin
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<blockquote data-quote="SimonCrox" data-source="post: 2064953" data-attributes="member: 388174"><p>I am not allowed to give specific treatment advice, but there is a really good article from New Zealand on the topic. Basically the metformin probably stops the end of the small bowel from absorbing B12 adequately; sometimes one can overcome this by giving a lot of B12 orally, although one USA study showed that this just did not work with taking metformin at same time, But sublingual B12 was as good as IM B12:-</p><p></p><p><a href="https://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-2019/2016/vol-129-no-1436-10-june-2016/6920" target="_blank">https://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-2019/2016/vol-129-no-1436-10-june-2016/6920</a></p><p></p><p>Thanks for the question - I did not know about sublingual B12, The sublingual B12 is still cyanocobalamin, which might not be great if low levels untreated and have neurological problems, but if low levels corrected with hydroxycobalamin jabs, should be fine since was what we used before early 1980's. Apparently, sublingual B-12 supplements often contain sugar substitutes such as sorbitol, mannitol or sucralose, which can cause gastro-intestinal upsets</p><p>Best wishes.</p></blockquote><p></p>
[QUOTE="SimonCrox, post: 2064953, member: 388174"] I am not allowed to give specific treatment advice, but there is a really good article from New Zealand on the topic. Basically the metformin probably stops the end of the small bowel from absorbing B12 adequately; sometimes one can overcome this by giving a lot of B12 orally, although one USA study showed that this just did not work with taking metformin at same time, But sublingual B12 was as good as IM B12:- [URL]https://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-2019/2016/vol-129-no-1436-10-june-2016/6920[/URL] Thanks for the question - I did not know about sublingual B12, The sublingual B12 is still cyanocobalamin, which might not be great if low levels untreated and have neurological problems, but if low levels corrected with hydroxycobalamin jabs, should be fine since was what we used before early 1980's. Apparently, sublingual B-12 supplements often contain sugar substitutes such as sorbitol, mannitol or sucralose, which can cause gastro-intestinal upsets Best wishes. [/QUOTE]
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