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Benefits of a T1 needing less insulin
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<blockquote data-quote="tim2000s" data-source="post: 952584" data-attributes="member: 30007"><p>I think the other aspect of this topic is the Hyperinsulinemia discussion (a la Fung and the fat emperor). Whilst a T1 by definition has Hyperinsulinemia due to the mechanism of insulin delivery, the degree to which it is in place may affect cardio-vascular health. In non-Ds, low levels of insulin correlate with better CV fitness. In the extreme world of the T1, higher levels of insulin may cause more rapid CV health issues such as quicker onset of Atherosclerosis, etc.</p><p></p><p>The various pieces of research available are rather variable as to whether increasing the insulin dose increases the already higher risk of CVD in T1s. There is research taken from reviewing medical records in the UK that links exogenous insulin in T2s to an increase in multiple death causing conditions, CVD, strokers and cancers being just some of them. I am unable to find the study, but there are multiple articles about it:</p><p><a href="http://medicalxpress.com/news/2014-12-insulin-dosage-diabetes-linked-death.html" target="_blank">http://medicalxpress.com/news/2014-12-insulin-dosage-diabetes-linked-death.html</a></p><p><a href="http://www.cardiff.ac.uk/news/view/77780-study-probes-insulin-effect" target="_blank">http://www.cardiff.ac.uk/news/view/77780-study-probes-insulin-effect</a></p><p></p><p>Quotes from those who ran it include:</p><p></p><p>"When compared to patients who received doses of less than 0.5 units [per kg of body weight], our findings indicate that patients receiving doses of between 1 to 1.5 units and more than 1.5 units were associated with a much greater death rate over time," says Principal Investigator, Professor Craig Currie, from Cardiff University School of Medicine.</p><p></p><p>"An estimated 15% of patients taking a dose of between 1 and 1.5 units had a 40% increased risk of death compared with the under-0.5 unit group, and the 5% of patients receiving more than 1.5 units had a 75% increased risk of death when compared with the same group."</p></blockquote><p></p>
[QUOTE="tim2000s, post: 952584, member: 30007"] I think the other aspect of this topic is the Hyperinsulinemia discussion (a la Fung and the fat emperor). Whilst a T1 by definition has Hyperinsulinemia due to the mechanism of insulin delivery, the degree to which it is in place may affect cardio-vascular health. In non-Ds, low levels of insulin correlate with better CV fitness. In the extreme world of the T1, higher levels of insulin may cause more rapid CV health issues such as quicker onset of Atherosclerosis, etc. The various pieces of research available are rather variable as to whether increasing the insulin dose increases the already higher risk of CVD in T1s. There is research taken from reviewing medical records in the UK that links exogenous insulin in T2s to an increase in multiple death causing conditions, CVD, strokers and cancers being just some of them. I am unable to find the study, but there are multiple articles about it: [URL]http://medicalxpress.com/news/2014-12-insulin-dosage-diabetes-linked-death.html[/URL] [URL]http://www.cardiff.ac.uk/news/view/77780-study-probes-insulin-effect[/URL] Quotes from those who ran it include: "When compared to patients who received doses of less than 0.5 units [per kg of body weight], our findings indicate that patients receiving doses of between 1 to 1.5 units and more than 1.5 units were associated with a much greater death rate over time," says Principal Investigator, Professor Craig Currie, from Cardiff University School of Medicine. "An estimated 15% of patients taking a dose of between 1 and 1.5 units had a 40% increased risk of death compared with the under-0.5 unit group, and the 5% of patients receiving more than 1.5 units had a 75% increased risk of death when compared with the same group." [/QUOTE]
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