Hi
@Archie Wood. Yes. I gave it a whirl as an alternative to metformin, understanding that berbrine is not regulated at all to the same extent as metformin is. Also, is not government subsidised. ($!)
I had a very difficult to live with side effect from metformin, which as well as being a mild appetite suppressant (good) it was also a mild depressant (not good!). Also had the usual, but mild, nausea side effect (not good).
I have a very minimal blood glucose response to metformin, as in a mere 1 mmol/L drop in my HBA1c, reflecting a 1 digit drop in my fasting blood glucose. (Not at all good!) My trusty GP and I decided I was in all likelihood one of the folks who metformin just doesn't work for, probably due to a gene difference which is naturally occuring in the population.
Berberine - no nausea which was great. No mild depressant effect. Also great. Same mild appetite suppressant which made my intermittent fasting routine easier. (great!). But also only a minimal effect on my blood glucose, same as metformin. (Not at all great!)