Usual Metformin is usually taken 3 times a day when you get to the maximum dose. All of the drug is released into your body within 30 minutes.
Slow release is designed to release the medication slowly into your body over 8 hours.
I'm thinking, perhaps with evening meal would be good for a person experiencing the "Dawn Phenomenon" - raised BG levels before breakfast. The peak effect is about eight hours after taking metformin prolonged release tablets, which means it could suppress the release of glucose by the liver that is happening in the hours leading up to getting up in the morning.
Lowest BG levels tend to be between 2 am and 4 am, hopefully this coinciding with the peak suppression from metformin slow release won't push one to hypoglycemia.
If one took it when going to bed the metformin Prolonged Release effectiveness would peak in time for getting up.
I'd be happy to hear of any opinions.
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