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Beta Cell De-Differentiation?
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<blockquote data-quote="Bubbleblower" data-source="post: 2487523" data-attributes="member: 540059"><p>I don’t like the term dedifferentiation either because we don’t know what is happening, some scientists proposed to use the term altered identity instead. There are studies showing high glucose changes the alpha to beta cell ratio, but it is complicated;</p><p></p><p><span style="font-size: 15px"><strong><a href="https://www.researchgate.net/publication/341528914_Dynamic_Change_of_b_to_a_Ratio_in_Islets_of_Chinese_People_With_Prediabetes_and_Type_2_Diabetes_Mellitus" target="_blank">Dynamic Change of β to α Ratio in Islets of Chinese People With Prediabetes and Type 2 Diabetes Mellitus</a></strong></span></p><p>The β to α ratio in islets (β/α) in PreD was significantly higher than that in ND, resulting from an increase of β cells and a decrease of α cells per islet, but that in T2D was significantly lower than that in ND, resulting from a decrease of β cells and an increase of α cells per islet. The β-cell percentage and β/α ratio positively correlated and α-cell percentage negatively correlated with HbA1c (glycated hemoglobin) in ND and PreD, but these correlations disappeared when T2D subjects were included.</p></blockquote><p></p>
[QUOTE="Bubbleblower, post: 2487523, member: 540059"] I don’t like the term dedifferentiation either because we don’t know what is happening, some scientists proposed to use the term altered identity instead. There are studies showing high glucose changes the alpha to beta cell ratio, but it is complicated; [SIZE=4][B][URL='https://www.researchgate.net/publication/341528914_Dynamic_Change_of_b_to_a_Ratio_in_Islets_of_Chinese_People_With_Prediabetes_and_Type_2_Diabetes_Mellitus']Dynamic Change of β to α Ratio in Islets of Chinese People With Prediabetes and Type 2 Diabetes Mellitus[/URL][/B][/SIZE] The β to α ratio in islets (β/α) in PreD was significantly higher than that in ND, resulting from an increase of β cells and a decrease of α cells per islet, but that in T2D was significantly lower than that in ND, resulting from a decrease of β cells and an increase of α cells per islet. The β-cell percentage and β/α ratio positively correlated and α-cell percentage negatively correlated with HbA1c (glycated hemoglobin) in ND and PreD, but these correlations disappeared when T2D subjects were included. [/QUOTE]
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