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Beta Cell De-Differentiation?
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<blockquote data-quote="Oldvatr" data-source="post: 2487524" data-attributes="member: 196898"><p>Found a clue that supports my theory, which is that fat and calcium easily combine to form soap which is generally insoluble. So the calcium gating that wakes up the beta cell to start the insulin production line could well be snaffled by ectopic fat (lipid fat) in the pancreas thus stopping beta cell function. Note that it is the Ca++ ion that is needed in the beta cell, and this is highly reactive.</p><p><a href="https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/547961" target="_blank">https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/547961</a></p><p></p><p>Note: although the pancreas is classed as adipose tissue, it does not normally get used for storing lipids. Certain conditions such as obesity or a high carb high fat diet can turn the pancreas into a fat store where fat gets stored outside of the normal places (i.e. ectopic fat) leading to stearosis.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2487524, member: 196898"] Found a clue that supports my theory, which is that fat and calcium easily combine to form soap which is generally insoluble. So the calcium gating that wakes up the beta cell to start the insulin production line could well be snaffled by ectopic fat (lipid fat) in the pancreas thus stopping beta cell function. Note that it is the Ca++ ion that is needed in the beta cell, and this is highly reactive. [URL]https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/547961[/URL] Note: although the pancreas is classed as adipose tissue, it does not normally get used for storing lipids. Certain conditions such as obesity or a high carb high fat diet can turn the pancreas into a fat store where fat gets stored outside of the normal places (i.e. ectopic fat) leading to stearosis. [/QUOTE]
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