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Beta Cell De-Differentiation?
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<blockquote data-quote="Oldvatr" data-source="post: 2487529" data-attributes="member: 196898"><p>Do we know what they used to measure this? I am presuming it was MRI scan and going by area, which is the normal way it is calculated. Or do they have some mechanism for actually counting the indivdual cells? Post mortem analysis shows that while areas may be different, masses do not, so in pathological samples, there was very little difference in the ratio calculated by mass rather than visual area. Also if betas are changing to alphas, they will not be packing their bags and physically moving to the alpha district, which is quite exclusive of the beta.</p><p></p><p>if there is increased glucagon output due to dedifferentiation, then it would be necessary to measure the stimulus and the inputs to the cell as well as its outputs. Or find some other way of decoupling the increase as being due to more alpha's rather than an increase in demand signal or increased nutrients,</p><p></p><p>The other thing they do not appear to have decoupled is the size of the cells. Is the change due to actual number of cells, or just the area aoccupied. If the cell sizes are unchnged, the the a/b ratio is valid. They do not seem to have taken cell size into account.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2487529, member: 196898"] Do we know what they used to measure this? I am presuming it was MRI scan and going by area, which is the normal way it is calculated. Or do they have some mechanism for actually counting the indivdual cells? Post mortem analysis shows that while areas may be different, masses do not, so in pathological samples, there was very little difference in the ratio calculated by mass rather than visual area. Also if betas are changing to alphas, they will not be packing their bags and physically moving to the alpha district, which is quite exclusive of the beta. if there is increased glucagon output due to dedifferentiation, then it would be necessary to measure the stimulus and the inputs to the cell as well as its outputs. Or find some other way of decoupling the increase as being due to more alpha's rather than an increase in demand signal or increased nutrients, The other thing they do not appear to have decoupled is the size of the cells. Is the change due to actual number of cells, or just the area aoccupied. If the cell sizes are unchnged, the the a/b ratio is valid. They do not seem to have taken cell size into account. [/QUOTE]
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