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Beta Cell De-Differentiation?
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<blockquote data-quote="Oldvatr" data-source="post: 2487738" data-attributes="member: 196898"><p>Note that the ND studies Counterpoint, Counterbalance and DIRECT showed that at best only 46% of the participants achieved remission, meaning that 64% did not. So the weight loss pthway does not apply to the general T2D population.</p><p></p><p>Found this research paper that relates to this topic</p><p><a href="https://www.sciencedirect.com/science/article/pii/S2212877819301760" target="_blank">https://www.sciencedirect.com/science/article/pii/S2212877819301760</a></p><p>I provides research independant of the ND studies that confirms adipose fat in the pancreas has a direct effect on insulin secretion</p><p>Edit to add: Having found the full text for that report, I have to warn that it is an endocrine smorgasbord, and will make your eyes water and your head spin. Not for the faint hearted. However, they use keyhole surgery and laser slicing to remove biopsy tissue in vivo for immediate anaylsis, so the meat is indeed fresh. They are able to do microbiological assayes to determine the various enzymes and toxins etc present and they do find crosstalk between the ectopic fat tissue and the beta cells.</p><p>I will include one experimental observation they found</p><p>"Surprisingly, the area of insulin positive cells determined using <em>in situ</em> immunohistological staining was unaltered both in pancreatic tissue with high level of adipocyte infiltration and in tissue from T2DM patients when compared to specimens of non-fatty and non-diabetic humans, respectively. This finding differs from observations made in <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/type-1-diabetes" target="_blank">T1DM</a> pancreata in the islets".</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2487738, member: 196898"] Note that the ND studies Counterpoint, Counterbalance and DIRECT showed that at best only 46% of the participants achieved remission, meaning that 64% did not. So the weight loss pthway does not apply to the general T2D population. Found this research paper that relates to this topic [URL]https://www.sciencedirect.com/science/article/pii/S2212877819301760[/URL] I provides research independant of the ND studies that confirms adipose fat in the pancreas has a direct effect on insulin secretion Edit to add: Having found the full text for that report, I have to warn that it is an endocrine smorgasbord, and will make your eyes water and your head spin. Not for the faint hearted. However, they use keyhole surgery and laser slicing to remove biopsy tissue in vivo for immediate anaylsis, so the meat is indeed fresh. They are able to do microbiological assayes to determine the various enzymes and toxins etc present and they do find crosstalk between the ectopic fat tissue and the beta cells. I will include one experimental observation they found "Surprisingly, the area of insulin positive cells determined using [I]in situ[/I] immunohistological staining was unaltered both in pancreatic tissue with high level of adipocyte infiltration and in tissue from T2DM patients when compared to specimens of non-fatty and non-diabetic humans, respectively. This finding differs from observations made in [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/type-1-diabetes']T1DM[/URL] pancreata in the islets". [/QUOTE]
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