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Beta Cell De-Differentiation?
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<blockquote data-quote="Ronancastled" data-source="post: 2488132" data-attributes="member: 517232"><p>Interesting that you mention Counterpoint/balance, can never remember.</p><p>Anyway, buried in the data is the 12 week follow up OGTT he administered to the "successful" candidates.</p><p><a href="https://link.springer.com/article/10.1007/s00125-011-2204-7" target="_blank">https://link.springer.com/article/10.1007/s00125-011-2204-7</a></p><p></p><p><img src="https://www.diabetes.co.uk/forum/attachments/capture1-png.52146/" alt="" class="fr-fic fr-dii fr-draggable " style="" /> </p><p></p><p>So basically they were still very very prediabetic.</p><p>Obviously prone to higher than normal spikes & further beta cell damage due to glucoxiticity.</p><p></p><p>The real breakthrough in my mind came in the 2 year follow up to Direct where they saw the slow return to normal 2nd phase secretion rates across 12 months, then maintaining at 24.</p><p><a href="https://diabetesjournals.org/diabetes/article/68/Supplement_1/66-OR/56507/66-OR-Remission-of-Type-2-Diabetes-for-Two-Years" target="_blank">https://diabetesjournals.org/diabetes/article/68/Supplement_1/66-OR/56507/66-OR-Remission-of-Type-2-Diabetes-for-Two-Years</a></p><p>In other words the 2011 Counter[?] cohort were given an OGTT far too early at 12 weeks.</p><p>Funnily enough though he never repeated the OGTT on the larger Direct group.</p></blockquote><p></p>
[QUOTE="Ronancastled, post: 2488132, member: 517232"] Interesting that you mention Counterpoint/balance, can never remember. Anyway, buried in the data is the 12 week follow up OGTT he administered to the "successful" candidates. [URL]https://link.springer.com/article/10.1007/s00125-011-2204-7[/URL] [IMG]https://www.diabetes.co.uk/forum/attachments/capture1-png.52146/[/IMG] So basically they were still very very prediabetic. Obviously prone to higher than normal spikes & further beta cell damage due to glucoxiticity. The real breakthrough in my mind came in the 2 year follow up to Direct where they saw the slow return to normal 2nd phase secretion rates across 12 months, then maintaining at 24. [URL]https://diabetesjournals.org/diabetes/article/68/Supplement_1/66-OR/56507/66-OR-Remission-of-Type-2-Diabetes-for-Two-Years[/URL] In other words the 2011 Counter[?] cohort were given an OGTT far too early at 12 weeks. Funnily enough though he never repeated the OGTT on the larger Direct group. [/QUOTE]
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