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Beta Cell De-Differentiation?
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<blockquote data-quote="Oldvatr" data-source="post: 2488272" data-attributes="member: 196898"><p>The paper I linked in Post#10 discusses the numeric and physical properties of the alpha cells. I believe alphas outnumber beta's by a factor of at least 50:1 in ND samples. Not the sort of number a guy with a microscope and exceedingly good eyesight can omfortably count in a lifetime. I believe that scannng electon microscopes (SEM) are used with a dye that makes the stained cells of interest fluoresce and a scintillator counts them automatically. I believe pixel size is a limting factor according to one paper I read recently. The other problem is that a SEM is a 2-D scan, but the pancreas is 3-D object.</p><p></p><p>The beta cell recovery after surgery is discussed in this paper</p><p><a href="https://pubmed.ncbi.nlm.nih.gov/22079939/" target="_blank">https://pubmed.ncbi.nlm.nih.gov/22079939/</a></p><p></p><p>The pancreas is made from precursor stem cells, but apparently the pancreas also has spare precursor cells that are differentiated with their correct mRNA but do not activate and remain dormant. The pancreatic surgery leaves many of these behind, and they become switched on to perform their beta cell function post surgery..</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2488272, member: 196898"] The paper I linked in Post#10 discusses the numeric and physical properties of the alpha cells. I believe alphas outnumber beta's by a factor of at least 50:1 in ND samples. Not the sort of number a guy with a microscope and exceedingly good eyesight can omfortably count in a lifetime. I believe that scannng electon microscopes (SEM) are used with a dye that makes the stained cells of interest fluoresce and a scintillator counts them automatically. I believe pixel size is a limting factor according to one paper I read recently. The other problem is that a SEM is a 2-D scan, but the pancreas is 3-D object. The beta cell recovery after surgery is discussed in this paper [URL]https://pubmed.ncbi.nlm.nih.gov/22079939/[/URL] The pancreas is made from precursor stem cells, but apparently the pancreas also has spare precursor cells that are differentiated with their correct mRNA but do not activate and remain dormant. The pancreatic surgery leaves many of these behind, and they become switched on to perform their beta cell function post surgery.. [/QUOTE]
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