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Message: <blockquote data-quote="Oldvatr" data-source="post: 2502868" data-attributes="member: 196898">The Beta cells use calcium to convert pre-insulin into insulin and c-peptide.  This insulin gets stored in the beta cells granules but does not release it until the potassium level increases which opens the door and allows the stored insulin out into the blood stream.  So blocking calcium flow to the pancreas is not a good idea.  it will probably clobber the Stage #1 insulin response, but that normally gets clobbered by T2D, but longer term it will probably just reduce the peak output giving a slower response.  Conversely if the drug only inhibits calcium going into the heart, then this would give more calcium for the beta cells, which may be what they are seeing.Interesting that it improves T1D beta cell function apparently.  Or am I misssing something?  Is it only during the honeymoon period?They only measured fasting blood sugars, so we do not know if insulin output improved, or insulin resistance was reduced by the drug.  An OGTT study is called for, methinks  Pity they did not measure any c-peptides.</blockquote>

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