bovine/porcine insulin

[goji]

Just wondered if any of you bright sparks out there know if bovine or porcine insulin has the exact same chemical structure as human insulin?

Any info much appreciated.

Thanks
goji x

 

[tubolard]

Goji,

Wikipedia has some detail about insulin, this page asserts that both bovine and porcine insulin are very close in structure to human insulin, however porcine insulin is the closest in structure.

Regards, Tubs.

 

[timo2]

Hello goji,

According to my uncle Google, the primary structures of bovine, porcine and human
insulin share the same layout, but there are slight variations in the exact sequence
of amino acids.

As Tubs has said, porcine insulin is the closest match to human, only swaping
alanine in place of threonine for amino acid number 30 on the B chain of its
primary structure(see picture below).
A close enough match for the boffins to say "ah, that'll do".

Regards,
timo.

 

[goji]

Thanks guys

That's most helpful. Without a degree in chemistry, I'd have had no chance at deciphering that info.

Goji