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<blockquote data-quote="Dennis" data-source="post: 31257" data-attributes="member: 1338"><p><strong>Re: Anyone use Byetta?</strong></p><p></p><p></p><p>Hi Fiona, and welcome to Tinam,</p><p>I not sure your idea would work Fiona. When a non-diabetic starts to eat, the arrival of food in the stomach triggers the production of hormones called GLP-1 and GIP. These hormones signal the pancreas to start producing insulin which will be needed once the carbs in the meal have been converted to sugar. This is called first-phase insulin production. Once the cycle has started then, with the continuing arrival of more food, the pancreas will continue to produce as much insulin as is needed to deal with the additional blood sugar. This production of insulin in response to the meal is second-phase production.</p><p></p><p>A problem that is now known to be quite common in type-2s is that part of our autoimmune system, an enzyme called DPP-4, attacks and destroys GLP-1 before it can reach the pancreas. So our pancreases never get the signal to start and so aren't ready when the blood sugars start to go up. Phase 2 then either doesn't happen or is a pretty half-hearted affair. This autoimmune attack is believed to affect as many as 40% of type-2s - but as yet less than 1% of type-2s are on Byetta. Byetta contains another hormone, exendin-4, which is very similar to GLP-1, but is not attacked by DPP-4. Your pancreas recognises the exendin as it's signal to start producing insulin. </p><p></p><p>If you take the Byetta shot then your first-phase production will start. But I'm not sure if the carbs in a few crackers would be enough to get the pancreas into second-phase production. First-phase production doesn't last very long so the risk is that, with no further food coming in, your pancreas will have shut down again before your main meal. You could try it but there is a danger that getting the first-phase going with insufficient carbs could result in a hypo. You might need a hypo-stop handy just in case.</p></blockquote><p></p>
[QUOTE="Dennis, post: 31257, member: 1338"] [b]Re: Anyone use Byetta?[/b] Hi Fiona, and welcome to Tinam, I not sure your idea would work Fiona. When a non-diabetic starts to eat, the arrival of food in the stomach triggers the production of hormones called GLP-1 and GIP. These hormones signal the pancreas to start producing insulin which will be needed once the carbs in the meal have been converted to sugar. This is called first-phase insulin production. Once the cycle has started then, with the continuing arrival of more food, the pancreas will continue to produce as much insulin as is needed to deal with the additional blood sugar. This production of insulin in response to the meal is second-phase production. A problem that is now known to be quite common in type-2s is that part of our autoimmune system, an enzyme called DPP-4, attacks and destroys GLP-1 before it can reach the pancreas. So our pancreases never get the signal to start and so aren't ready when the blood sugars start to go up. Phase 2 then either doesn't happen or is a pretty half-hearted affair. This autoimmune attack is believed to affect as many as 40% of type-2s - but as yet less than 1% of type-2s are on Byetta. Byetta contains another hormone, exendin-4, which is very similar to GLP-1, but is not attacked by DPP-4. Your pancreas recognises the exendin as it's signal to start producing insulin. If you take the Byetta shot then your first-phase production will start. But I'm not sure if the carbs in a few crackers would be enough to get the pancreas into second-phase production. First-phase production doesn't last very long so the risk is that, with no further food coming in, your pancreas will have shut down again before your main meal. You could try it but there is a danger that getting the first-phase going with insufficient carbs could result in a hypo. You might need a hypo-stop handy just in case. [/QUOTE]
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