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Message: <blockquote data-quote="martinbuchan" data-source="post: 3622" data-attributes="member: 718">Dennis- animal studies show GLPII drugs stimulate bets islet cells to fuction again- could be useful for someone like me who is fairly insuln resistent and pruduces little insulin. The studies on exenatide in insulin users are on going, hence the licence restrictions at the moment. I think it shows in type 2 how the other metabolic effects contribute to hyperglycaemic. It makes me wonder if that this is the primary pathology- increased glucagon leads to hyperinsulinaemia leasds to insulin resistance.....  and so on. the  prediabetic state glucose intolerance might suggest this. Use of these drugs may be useful partly as an insulin sparing effect (like metformin for me). Still worthwhile. Cost wise, my Levemir costs more than Byetta for the dosage I am on. Less insulin inbtake would help me lose weight and so on.Once I am stabilise with my foot infection I will push for either class of drug again. CheersMarty B</blockquote>

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