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<blockquote data-quote="Dennis" data-source="post: 48703" data-attributes="member: 1338"><p><strong>Re: Anyone use Byetta?</strong></p><p></p><p>Hi Fiona,</p><p></p><p>I'm not sure where this idea came from that the longer you leave it between injection and eating then the more effective it will be - certainly not from the manufacturers because they have never claimed this. It is not mentioned in either their patient or practitioner literature. The only thing they do say is that the longer the gap then the more likely you are to experience the side effects - as you are now finding.</p><p></p><p>The idea of Byetta is that it sets off first phase insulin production by your pancreas. In a non-diabetic person first phase is triggered by the stomach recognising that food has arrived and sending messages to the pancreas to get started. The pancreas starts insulin production within a few minutes of the first food arriving, before the food has even been converted into glucose. Depending on what type of carbohydrate is in the food, the conversion of carbs into glucose can take anything from a couple of minutes to more than an hour. This would indicate that logically, the ideal time to take Byetta for it to have maximum effect would be around 15-30 minutes before eating. That would get the pancreas getting its first phase production nicely into gear just in time for the first increases in blood sugar. And also avoids side effects.</p></blockquote><p></p>
[QUOTE="Dennis, post: 48703, member: 1338"] [b]Re: Anyone use Byetta?[/b] Hi Fiona, I'm not sure where this idea came from that the longer you leave it between injection and eating then the more effective it will be - certainly not from the manufacturers because they have never claimed this. It is not mentioned in either their patient or practitioner literature. The only thing they do say is that the longer the gap then the more likely you are to experience the side effects - as you are now finding. The idea of Byetta is that it sets off first phase insulin production by your pancreas. In a non-diabetic person first phase is triggered by the stomach recognising that food has arrived and sending messages to the pancreas to get started. The pancreas starts insulin production within a few minutes of the first food arriving, before the food has even been converted into glucose. Depending on what type of carbohydrate is in the food, the conversion of carbs into glucose can take anything from a couple of minutes to more than an hour. This would indicate that logically, the ideal time to take Byetta for it to have maximum effect would be around 15-30 minutes before eating. That would get the pancreas getting its first phase production nicely into gear just in time for the first increases in blood sugar. And also avoids side effects. [/QUOTE]
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