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<blockquote data-quote="Dennis" data-source="post: 11820" data-attributes="member: 1338"><p>Hi leonad and welcome to the forum.</p><p>Sorry to hear that you are suffering at the moment on byetta, but in all honesty I am not surprised. The manufacturers give very clear instructions that you must be on the 5mg dose for a minimum of 30 days before you are moved up to the 10mg dose. This drug is very powerful and, provided the instructions are followed the nausea should wear off in a week to 10 days. Once you have acclimatised to the 5 dose and move up to the 10m dose you experience further nausea for a week to 10 days. Unfortunately I have heard of several in the UK and the US who have been put on the 10 dose too early and in almost every case have had to come off it altogether because the sickness is too severe. Its such a shame - if only the "specialists" would just read the instructions.</p><p></p><p>You will find that all UK users are on other meds as well. Byetta is only licenced in the UK for use as a secondary treatment, so can only be used in conjunction with a biguanide (Metformin or Glucophage), a sulphonylurea (Glyburide, Gliclazide, Glimepiride, Glipizide), or a thiazolidinedione (pioglitazone or rosiglitazone). I am on Glucophage SR (the slow-release metformin) and a very small dose of Amaryl (glimepiride). I next see my consultant in 2 weeks and I expect he will take me off the Amaryl because my BS has been steadily improving since I started on byetta in August last year. The lizard spit has also helped me lose weight, but in fits and starts as I explained a few posts back.</p><p></p><p>Your experience of the sickness is a known side effect and if it doesn't improve, you might want to suggest to your diabetes team that they put you back on the 5 pen so that you can acclimatise to it as the manufacturers advise. The loss of appetite is also expected - this is what byetta is supposed to do. But the upset tummy will almost certainly be caused by something else - metformin is the usual culprit. Byetta slows down the passage of food through the gut so constipation is a more commonly seen effect!</p><p></p><p>Its always good to see another lizard lover on the site so I hope you will stay with us and share your experiences on byetta.</p></blockquote><p></p>
[QUOTE="Dennis, post: 11820, member: 1338"] Hi leonad and welcome to the forum. Sorry to hear that you are suffering at the moment on byetta, but in all honesty I am not surprised. The manufacturers give very clear instructions that you must be on the 5mg dose for a minimum of 30 days before you are moved up to the 10mg dose. This drug is very powerful and, provided the instructions are followed the nausea should wear off in a week to 10 days. Once you have acclimatised to the 5 dose and move up to the 10m dose you experience further nausea for a week to 10 days. Unfortunately I have heard of several in the UK and the US who have been put on the 10 dose too early and in almost every case have had to come off it altogether because the sickness is too severe. Its such a shame - if only the "specialists" would just read the instructions. You will find that all UK users are on other meds as well. Byetta is only licenced in the UK for use as a secondary treatment, so can only be used in conjunction with a biguanide (Metformin or Glucophage), a sulphonylurea (Glyburide, Gliclazide, Glimepiride, Glipizide), or a thiazolidinedione (pioglitazone or rosiglitazone). I am on Glucophage SR (the slow-release metformin) and a very small dose of Amaryl (glimepiride). I next see my consultant in 2 weeks and I expect he will take me off the Amaryl because my BS has been steadily improving since I started on byetta in August last year. The lizard spit has also helped me lose weight, but in fits and starts as I explained a few posts back. Your experience of the sickness is a known side effect and if it doesn't improve, you might want to suggest to your diabetes team that they put you back on the 5 pen so that you can acclimatise to it as the manufacturers advise. The loss of appetite is also expected - this is what byetta is supposed to do. But the upset tummy will almost certainly be caused by something else - metformin is the usual culprit. Byetta slows down the passage of food through the gut so constipation is a more commonly seen effect! Its always good to see another lizard lover on the site so I hope you will stay with us and share your experiences on byetta. [/QUOTE]
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