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C Peptide Results are in- I'm producing a good amount of insulin! Type 1?!
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<blockquote data-quote="JohnEGreen" data-source="post: 2055635" data-attributes="member: 223921"><p>The discoverer of proinsulin was Donald F. Steiner MD. His work led directly to the development of the C-Peptide test.</p><p></p><p>"</p><p>The discovery of proinsulin established the field of protein-precursor processing, paving the way to understanding how many other peptide hormones—as well as neuropeptides in the brain and endocrine system—are made and processed. Don and his colleagues later discovered the larger precursor of proinsulin, which they termed preproinsulin. This was a major advance for the understanding of peptide and prohormone processing generally. Don’s work also made major contributions to the understanding of the class of enzymes, termed prohormone convertases, that covert proinsulin to insulin along with other processing functions. His insights helped colleagues all over the world, as he traveled widely and was a frequent keynote speaker. Don had many collaborators throughout the United States, Europe, Japan, and Israel. He was an honorary member of the European Association for the Study of Diabetes.</p><p>The immunoassay that Don and Arthur Rubenstein developed for the C-peptide of proinsulin provided a critical independent indicator of insulin secretion, as further developed by Kenneth Polonsky and many others (3, 4). This immunoassay has become a standard tool in the diagnosis of insulin-secreting tumors of the pancreas and the evaluation of the success of islet transplants.</p><p>The discovery of proinsulin enabled the pharmaceutical industry to improve the purity of insulin preparations extracted from animals and paved the way for biosynthetic human insulin production. The immunological characterization of the proinsulin molecule allowed the pharmaceutical industry to introduce improved methods of purification of insulin to yield monocomponent insulin, leading to insulin preparations that were less likely to provoke an immune response. Don and his colleagues demonstrated that proinsulin could be cleaved to mature insulin by combined treatment with trypsin and carboxypeptidase B, which became the basis for the industrial production of recombinant human insulin (5). His work enhanced the management of diabetes and created a better life for millions of individuals with diabetes worldwide."</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313841/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313841/</a></p></blockquote><p></p>
[QUOTE="JohnEGreen, post: 2055635, member: 223921"] The discoverer of proinsulin was Donald F. Steiner MD. His work led directly to the development of the C-Peptide test. " The discovery of proinsulin established the field of protein-precursor processing, paving the way to understanding how many other peptide hormones—as well as neuropeptides in the brain and endocrine system—are made and processed. Don and his colleagues later discovered the larger precursor of proinsulin, which they termed preproinsulin. This was a major advance for the understanding of peptide and prohormone processing generally. Don’s work also made major contributions to the understanding of the class of enzymes, termed prohormone convertases, that covert proinsulin to insulin along with other processing functions. His insights helped colleagues all over the world, as he traveled widely and was a frequent keynote speaker. Don had many collaborators throughout the United States, Europe, Japan, and Israel. He was an honorary member of the European Association for the Study of Diabetes. The immunoassay that Don and Arthur Rubenstein developed for the C-peptide of proinsulin provided a critical independent indicator of insulin secretion, as further developed by Kenneth Polonsky and many others (3, 4). This immunoassay has become a standard tool in the diagnosis of insulin-secreting tumors of the pancreas and the evaluation of the success of islet transplants. The discovery of proinsulin enabled the pharmaceutical industry to improve the purity of insulin preparations extracted from animals and paved the way for biosynthetic human insulin production. The immunological characterization of the proinsulin molecule allowed the pharmaceutical industry to introduce improved methods of purification of insulin to yield monocomponent insulin, leading to insulin preparations that were less likely to provoke an immune response. Don and his colleagues demonstrated that proinsulin could be cleaved to mature insulin by combined treatment with trypsin and carboxypeptidase B, which became the basis for the industrial production of recombinant human insulin (5). His work enhanced the management of diabetes and created a better life for millions of individuals with diabetes worldwide." [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313841/[/URL] [/QUOTE]
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