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Can hba1c be too low?
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<blockquote data-quote="NoCrbs4Me" data-source="post: 706611" data-attributes="member: 113206"><p>[ATTACH]9577[/ATTACH] </p><p><span style="font-size: 15px">The graph is from a 2002 paper that had the objective of defining the relationship between HbA1c and mean plasma glucose levels in type 1 diabetics. There are 1,439 points in the graph. The bottom axis is obviously HbA1c. The vertical graph is mean plasma glucose, which was estimated from seven point capillary blood glucose profiles (premeal, postmeal and bed time). They plotted up the data and obtained a regression line. This study was done before continuous blood glucose monitors were common and before the HbA1c lab test method was standardized, but it was the only plot I found yesterday. </span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px">However, I did find an updated (2012) one today that is less scattered (<a href="http://www.medsci.org/v09p0665.htm" target="_blank">http://www.medsci.org/v09p0665.htm</a>):</span></p><p><span style="font-size: 15px"></span></p><p>[ATTACH=full]9578[/ATTACH] </p><p><span style="font-size: 15px">"Figure 3. The A1c-Derived Average Glucose (ADAG) Study Group demonstrated that HbA1c correlates well with average glucose (AG) (R2 = 0.84), however, although 90% of HbA1c concentrations predicted the average measured glucose within ± 15%, significant deviations were observed. The regression equation is: Calculated AG <em>(mg/dL) </em>= 28.7 x HbA1c <em>(%) </em>- 46.7."</span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px">So my HbA1c of 6% could mean an average blood glucose of 7 mmol/L +/- 1 (or from 6 to 8 mmol/L). Or, I could be outside the 90% and it could be very different. You can see from the graph that HbA1cs of 6% correlated to average glucose values of from 100 to 150 mg/L (5.6 to 8.3 mmol/L).</span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px">The more I read about the HbA1c test, the less weight I put on it and the more weight I put on my home blood glucose meter, which isn't all that accurate either.</span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"></span></p></blockquote><p></p>
[QUOTE="NoCrbs4Me, post: 706611, member: 113206"] [ATTACH]9577[/ATTACH] [SIZE=4]The graph is from a 2002 paper that had the objective of defining the relationship between HbA1c and mean plasma glucose levels in type 1 diabetics. There are 1,439 points in the graph. The bottom axis is obviously HbA1c. The vertical graph is mean plasma glucose, which was estimated from seven point capillary blood glucose profiles (premeal, postmeal and bed time). They plotted up the data and obtained a regression line. This study was done before continuous blood glucose monitors were common and before the HbA1c lab test method was standardized, but it was the only plot I found yesterday. However, I did find an updated (2012) one today that is less scattered ([url]http://www.medsci.org/v09p0665.htm[/url]): [/SIZE] [ATTACH=full]9578[/ATTACH] [SIZE=4]"Figure 3. The A1c-Derived Average Glucose (ADAG) Study Group demonstrated that HbA1c correlates well with average glucose (AG) (R2 = 0.84), however, although 90% of HbA1c concentrations predicted the average measured glucose within ± 15%, significant deviations were observed. The regression equation is: Calculated AG [I](mg/dL) [/I]= 28.7 x HbA1c [I](%) [/I]- 46.7." So my HbA1c of 6% could mean an average blood glucose of 7 mmol/L +/- 1 (or from 6 to 8 mmol/L). Or, I could be outside the 90% and it could be very different. You can see from the graph that HbA1cs of 6% correlated to average glucose values of from 100 to 150 mg/L (5.6 to 8.3 mmol/L). The more I read about the HbA1c test, the less weight I put on it and the more weight I put on my home blood glucose meter, which isn't all that accurate either. [/SIZE] [/QUOTE]
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