Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Type 2 Diabetes
Can hba1c be too low?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="pavlosn" data-source="post: 708158" data-attributes="member: 22572"><p>Can you please explain this further or provide a relevant link.</p><p></p><p>As I currently understand it hba1c ( in % terms at least) is a measure of the proportion of our hemoglobin that has been glycated I.e has a glucose particle attached.</p><p></p><p>The rate at which hemoglobin is glycated and hence Hba1c depends on the concentration of glucose in the blood. The higher concentration of glucose the higher the rate at which hemoglobin will be glycated and the higher the Hba1c.</p><p></p><p>A hypo is a period when our glucose concentration although lower than normal is still positive, not negative.</p><p></p><p>During a hypo I would expect hemoglobin to continue to be glycated but at a slower rate (assuming that there is no minimum glucose threshold for glycation to occur).</p><p></p><p>So a hypo, being lower than our average glucose count, will cause our average to decrease, while actually still causing hemoglobin to be glycated (albeit at a lower rate), so still contributing to increased hba1c.</p><p></p><p>The complication is that our blood cells are continuously being renewed (on average every three months) so theoretically if the rate of increase of glycated cells slows down beyond the rate at which the glycated cells are replaced with fresh ones, then hypos would cause the proportion of glycated hemoglobin and hence hbA1c to decrease. I do not know if this is a practical possibility though.</p></blockquote><p></p>
[QUOTE="pavlosn, post: 708158, member: 22572"] Can you please explain this further or provide a relevant link. As I currently understand it hba1c ( in % terms at least) is a measure of the proportion of our hemoglobin that has been glycated I.e has a glucose particle attached. The rate at which hemoglobin is glycated and hence Hba1c depends on the concentration of glucose in the blood. The higher concentration of glucose the higher the rate at which hemoglobin will be glycated and the higher the Hba1c. A hypo is a period when our glucose concentration although lower than normal is still positive, not negative. During a hypo I would expect hemoglobin to continue to be glycated but at a slower rate (assuming that there is no minimum glucose threshold for glycation to occur). So a hypo, being lower than our average glucose count, will cause our average to decrease, while actually still causing hemoglobin to be glycated (albeit at a lower rate), so still contributing to increased hba1c. The complication is that our blood cells are continuously being renewed (on average every three months) so theoretically if the rate of increase of glycated cells slows down beyond the rate at which the glycated cells are replaced with fresh ones, then hypos would cause the proportion of glycated hemoglobin and hence hbA1c to decrease. I do not know if this is a practical possibility though. [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Type 2 Diabetes
Can hba1c be too low?
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…