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Type 2 Diabetes
Can hba1c be too low?
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<blockquote data-quote="sanguine" data-source="post: 708168" data-attributes="member: 101256"><p>I think you're both right. Rate of glycation (or whatever the word is) will depend on the BG level in the blood. This acts on the positive side of the HbA1c balance. The negative side is when glycated blood cells die and are replaced by new blood cells, but the haemoglobin cells can't be 'deglycated' when still viable. The longevity of blood cells varies and is a subject in itself, but as a rule of thumb we assume it to be around 2-3 months.</p><p></p><p>As for hypos, I would expect glycation to still be occurring at a reduced rate as Pavlos says (we may be wrong on this) but unless you have them frequently and for long periods I can't see that it would have much affect on the HbA1c any more than an occasional spiky meal would.</p></blockquote><p></p>
[QUOTE="sanguine, post: 708168, member: 101256"] I think you're both right. Rate of glycation (or whatever the word is) will depend on the BG level in the blood. This acts on the positive side of the HbA1c balance. The negative side is when glycated blood cells die and are replaced by new blood cells, but the haemoglobin cells can't be 'deglycated' when still viable. The longevity of blood cells varies and is a subject in itself, but as a rule of thumb we assume it to be around 2-3 months. As for hypos, I would expect glycation to still be occurring at a reduced rate as Pavlos says (we may be wrong on this) but unless you have them frequently and for long periods I can't see that it would have much affect on the HbA1c any more than an occasional spiky meal would. [/QUOTE]
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