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Type 2 Diabetes
Can hba1c be too low?
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<blockquote data-quote="LucySW" data-source="post: 708170" data-attributes="member: 113749"><p>My understanding is that the rate of hemoglobin glycation will be lower not only during hypos, but whenever blood glucose levels are low to normal. That is, the rate will be a curve, not a line. So it will accelerate gradually, rather than going from hypo level in a straight line up to high blood glucose levels. </p><p></p><p>So the factor determining low HbA1c would be the total amount of time spent with blood glucose levels below a certain threshold, the threshold at which for each individual at any given time the rate of glycation increases. Which is a circular definition of course. </p><p></p><p>I shall have to go away and do some work on this.</p></blockquote><p></p>
[QUOTE="LucySW, post: 708170, member: 113749"] My understanding is that the rate of hemoglobin glycation will be lower not only during hypos, but whenever blood glucose levels are low to normal. That is, the rate will be a curve, not a line. So it will accelerate gradually, rather than going from hypo level in a straight line up to high blood glucose levels. So the factor determining low HbA1c would be the total amount of time spent with blood glucose levels below a certain threshold, the threshold at which for each individual at any given time the rate of glycation increases. Which is a circular definition of course. I shall have to go away and do some work on this. [/QUOTE]
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