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Message: <blockquote data-quote="xyzzy" data-source="post: 1354943" data-attributes="member: 40343">Nope that's not entirely true. I agree there is no definitive evidence but there are many studies that link sulfonylureas to a significant increased risk of pancreatic cancer and a large study in 2013 found a 58% increase in all-cause mortality as opposed to those like me who just take Metformin or those who control purely by diet.see <a href="http://www.medpagetoday.com/MeetingCoverage/EASDEndo/41886" target="_blank">Sulfonylureas May Raise Death Risk</a>as one of many example studies.On the purely anecdotal evidence of the many thousands of members of this site who have posted over the last 10 years those T2's that avoid any insulin stimulating drug by primarily managing their diet have managed to slow, stop or reverse the progression of the disease far better than those who have used them. While I accept this is not evidence that sulfonylureas cause burn out I think it does suggest those who do use insulin stimulants find the disease progresses faster for whatever reason.There are also other negatives to sulfonylureas in the sense they work all the time so if makes it more difficult to lose weight even if you're trying and of course there is an associated hypo risk if you forget to eat enough carbohydrates. The more modern DPP-4 drugs like Januvia are better in that they only stimulate when you eat however there are studies showing these have their own set of risks. Better appear to be the new SGLT2 Inhibitors as like Metformin they work without increasing insulin production.</blockquote>

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