I agree with the above. It may not be a physical change in the brain but high blood sugars can certainly make a person feel very irritated, anxious, generally annoyed/angry. In addition the daily stress of dealing with a chronic disease can be a very heavy weight on ones shoulders and I can see lead to depression, anxiety, panic attacks and general change in behavior over time depending on how it is able to be handled.
I would contact his management team and let them know so that they can provide the required aid. All the best, hope you can sort out this problem swiftly.