Hi this is all new to me also. I've been on Januvia for exactly a week now and I feel so much better! I was on Glucophage x4.a day with my Actos and I put on so much weight I was so depressed. Now off the Actos and my appetite has gone. Have cut down on the Gluco to x2 a day but just want to ask anyone if it's ok to skip the odd meal when you're just not hungry? It just feels wrong to eat when your not hungry and you need to lose weight anyway! Any advice?