Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Ask A Question
Cholesterol
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="KennyA" data-source="post: 2692727" data-attributes="member: 517579"><p>I don't think this paper (thank you for posting it) says what you think it does. It rather confirms the HUNT2 findings - which also show a similar u-shaped effect. For example, the authors say:</p><p></p><p><em>It is unclear whether associations between total cholesterol (TC) levels and all-cause mortality and the optimal TC ranges for lowest mortality vary by sex and age.</em></p><p><em></em></p><p><em>“The lower, the better” cholesterol hypothesis has been accepted by many health professionals. However, the statin trials were mainly performed in persons at a high risk of heart disease, especially in men with manifest CVD, in whom heart disease mortality constituted approximately 50% of all deaths.</em></p><p><em></em></p><p><em>In the current study, however, TC levels of 210–249 mg/dL (my note: 5.2 mmol/lto approx 6.5 mmol/l - this is usually defined as "high" or "borderline high" total cholesterol) and approximately 200–240 mg/dL were associated with the lowest mortality in the categorical and spline analyses, respectively. </em></p><p><em></em></p><p><em>Even within CVD subtypes, TC ranges associated with lowest risk have not been consistent. For example, for stroke, TC levels <200 mg/dL were not associated with the lowest mortality in prospective cohort studies, and randomized trials have not provided clear evidence of whether lipid-lowering therapies, including statins, reduce stroke mortality. Hemorrhagic stroke, respiratory diseases (especially chronic obstructive pulmonary disease), digestive diseases (especially liver disease), and several cancers have been suggested to be associated with lower TC levels; thus, the ranges associated with lowest risk might be even higher for these diseases than those for all-cause mortality. </em></p><p></p><p>It's well worth a read in full. It provides additional evidence that the "low cholesterol" approach is not one that results in decreased risk.</p></blockquote><p></p>
[QUOTE="KennyA, post: 2692727, member: 517579"] I don't think this paper (thank you for posting it) says what you think it does. It rather confirms the HUNT2 findings - which also show a similar u-shaped effect. For example, the authors say: [I]It is unclear whether associations between total cholesterol (TC) levels and all-cause mortality and the optimal TC ranges for lowest mortality vary by sex and age. “The lower, the better” cholesterol hypothesis has been accepted by many health professionals. However, the statin trials were mainly performed in persons at a high risk of heart disease, especially in men with manifest CVD, in whom heart disease mortality constituted approximately 50% of all deaths. In the current study, however, TC levels of 210–249 mg/dL (my note: 5.2 mmol/lto approx 6.5 mmol/l - this is usually defined as "high" or "borderline high" total cholesterol) and approximately 200–240 mg/dL were associated with the lowest mortality in the categorical and spline analyses, respectively. Even within CVD subtypes, TC ranges associated with lowest risk have not been consistent. For example, for stroke, TC levels <200 mg/dL were not associated with the lowest mortality in prospective cohort studies, and randomized trials have not provided clear evidence of whether lipid-lowering therapies, including statins, reduce stroke mortality. Hemorrhagic stroke, respiratory diseases (especially chronic obstructive pulmonary disease), digestive diseases (especially liver disease), and several cancers have been suggested to be associated with lower TC levels; thus, the ranges associated with lowest risk might be even higher for these diseases than those for all-cause mortality. [/I] It's well worth a read in full. It provides additional evidence that the "low cholesterol" approach is not one that results in decreased risk. [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Ask A Question
Cholesterol
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…