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Choosing insulin? And experience of Avandia?
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<blockquote data-quote="rach" data-source="post: 43288" data-attributes="member: 13157"><p>Thanks very much for all your advice.</p><p></p><p>Trinkwasser: I have been tried on metformin (metfartin...love the name!) but couldn't tolerate it - severe vomiting/diarrhoea. I know these reduce with time but no vomiting/diarrhoea was at all practical if I am to carry on with my work and when I mentioned it was taken off it immediately. I've been told I'm MODY and just produce low amounts of insulin (not have resistance to it) and that that was why gliclazide initally worked so well. I had thought the sudden decrease in blood sugar levels was due to my pancreas giving up but might it be possible it is actually rapidly increasing insulin resistance? My lipids were good in November - cholesterol 4.2, triglycerides 0.8, HDL 2.1, LDL 1.3</p><p></p><p>Trinkwasser and Hana, thanks for the suggestion of carb reduction - I have done that a fair bit. I now eat 80-120g carbs a day (much to the dislike of my GP...she was all eat lots and lots of pasta - hmm). I'm not sure I can really go any lower.... is this likely to be low enough to have an effect? I noticed a huge effect when I first cut down (from over 200g/day). </p><p></p><p>Dennis: Thank you for the insight into insulin's effects on life. Am I right that it is still possible to drive providing you don't have "debilitating hypos"? (And do you have any idea what debilitating hypos are?!). I found it harder to look up info on travel and car insurance. What sorts of difficulties does it cause? Are they harder to get and cost more, or impossible? Thanks too for the insight on rosiglitazone...they don't tell you ANY of that do they?? Dreading the idea of weight gain, gliclazide has already put me up half a stone eating the same number of calories, which when I weighed 8 stone before is a significant gain. I will watch out for that - unfortunately the consultant didn't take me very seriously about the weight gain when I last saw her as she said I have a normal BMI so it didn't matter. But 5 stone is a lot, and you're right, weight takes ages to come off but no time to go on. Your effects on rosiglitazone sound awful - I'll be watching out. Hopefully I might be in the small number of unaffected people thought... Can always hope!</p><p></p><p>Thanks again for all your help,</p><p>Rachael</p></blockquote><p></p>
[QUOTE="rach, post: 43288, member: 13157"] Thanks very much for all your advice. Trinkwasser: I have been tried on metformin (metfartin...love the name!) but couldn't tolerate it - severe vomiting/diarrhoea. I know these reduce with time but no vomiting/diarrhoea was at all practical if I am to carry on with my work and when I mentioned it was taken off it immediately. I've been told I'm MODY and just produce low amounts of insulin (not have resistance to it) and that that was why gliclazide initally worked so well. I had thought the sudden decrease in blood sugar levels was due to my pancreas giving up but might it be possible it is actually rapidly increasing insulin resistance? My lipids were good in November - cholesterol 4.2, triglycerides 0.8, HDL 2.1, LDL 1.3 Trinkwasser and Hana, thanks for the suggestion of carb reduction - I have done that a fair bit. I now eat 80-120g carbs a day (much to the dislike of my GP...she was all eat lots and lots of pasta - hmm). I'm not sure I can really go any lower.... is this likely to be low enough to have an effect? I noticed a huge effect when I first cut down (from over 200g/day). Dennis: Thank you for the insight into insulin's effects on life. Am I right that it is still possible to drive providing you don't have "debilitating hypos"? (And do you have any idea what debilitating hypos are?!). I found it harder to look up info on travel and car insurance. What sorts of difficulties does it cause? Are they harder to get and cost more, or impossible? Thanks too for the insight on rosiglitazone...they don't tell you ANY of that do they?? Dreading the idea of weight gain, gliclazide has already put me up half a stone eating the same number of calories, which when I weighed 8 stone before is a significant gain. I will watch out for that - unfortunately the consultant didn't take me very seriously about the weight gain when I last saw her as she said I have a normal BMI so it didn't matter. But 5 stone is a lot, and you're right, weight takes ages to come off but no time to go on. Your effects on rosiglitazone sound awful - I'll be watching out. Hopefully I might be in the small number of unaffected people thought... Can always hope! Thanks again for all your help, Rachael [/QUOTE]
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