JohnEGreen
Master
- Messages
- 14,002
- Location
- Nottinghamshire
- Type of diabetes
- Other
- Treatment type
- Diet only
- Dislikes
- Tripe and Onions
I have just started taking this medication and was wondering if any one else here is taking it and if they have had any problems with it.
As I just found this on the net.
Co-trimoxazole-induced hypoglycaemia in an immunosuppressed intensive care patient
"
Abstract
An 18-year-old female inpatient on a neurosciences intensive care unitwith new onset super-refractory epilepsy became hypoglycaemic 48 h after commencing co-trimoxazole. She had been placed on this for prophylaxis against Pneumocystis jiroveci infection in the context of significant immunosuppression with high-dose corticosteroid therapy. In order to maintain glucose control, she required a continuous infusion of 10% dextrose at rates of 15–25 ml/h. Recurrent attempts to wean this were limited by further hypoglycaemia, until she spontaneously regained normoglycaemia after 73 days. This case report will discuss this unusual case of refractory hypoglycaemia, and the proposed pathophysiology of hypoglycaemia related to co-trimoxazole therapy."
"Background
Pneumocystis jiroveci pneumonia is a life-threatening condition associated with significant immunosuppression. As this can be life-threatening, it is advised that patients receiving over 20 mg prednisolone for over one month should be commenced on prophylactic antibiotics.1 Co-trimoxazole (combination of trimethoprim and sulfamethoxazole in a 1:5 ratio) is first line for prophylaxis due to its efficacy.1 However, it carries a high incidence of adverse effects, including hypoglycaemia."
http://journals.sagepub.com/doi/full/10.1177/1751143716660330
I know this is an intensive care journal but though not in an ICU the reasons I think apply to me.
As I just found this on the net.
Co-trimoxazole-induced hypoglycaemia in an immunosuppressed intensive care patient
"
Abstract
An 18-year-old female inpatient on a neurosciences intensive care unitwith new onset super-refractory epilepsy became hypoglycaemic 48 h after commencing co-trimoxazole. She had been placed on this for prophylaxis against Pneumocystis jiroveci infection in the context of significant immunosuppression with high-dose corticosteroid therapy. In order to maintain glucose control, she required a continuous infusion of 10% dextrose at rates of 15–25 ml/h. Recurrent attempts to wean this were limited by further hypoglycaemia, until she spontaneously regained normoglycaemia after 73 days. This case report will discuss this unusual case of refractory hypoglycaemia, and the proposed pathophysiology of hypoglycaemia related to co-trimoxazole therapy."
"Background
Pneumocystis jiroveci pneumonia is a life-threatening condition associated with significant immunosuppression. As this can be life-threatening, it is advised that patients receiving over 20 mg prednisolone for over one month should be commenced on prophylactic antibiotics.1 Co-trimoxazole (combination of trimethoprim and sulfamethoxazole in a 1:5 ratio) is first line for prophylaxis due to its efficacy.1 However, it carries a high incidence of adverse effects, including hypoglycaemia."
http://journals.sagepub.com/doi/full/10.1177/1751143716660330
I know this is an intensive care journal but though not in an ICU the reasons I think apply to me.