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<blockquote data-quote="GVA2" data-source="post: 1106710" data-attributes="member: 212630"><p>No test has 100% sensitivity or specificity. A1C has a n error rate of +/- 0.5% or 5mmol/Mol. OGTT are also very variable and much more dependant on subject and operator adhering to the protocol. 3 days of adequate CHO intake, correct fasting period and correct timing of venesection. Even when carried out correctly it, has significant variability. Another rather bizarre aspect of GTTs is that we give the same (huge) dose of glucose to a 55kg woman as we would to a 110kg male.This test is an anachronism. I very rarely order n OGTT for patients other than for gestational diabetes, for very specific reasons.</p><p>Dysglycemia is part of a continuum. Lower glucose is desirable, and attempts to achieve lower BGLs are to be encouraged , as long as the risk benefit equation falls on the right side.</p><p>It's easy to get fixated on the numbers. They are a very important and useful barometers that help track progress and quantify risk, but it's easy to be distracted by the minutiae.</p></blockquote><p></p>
[QUOTE="GVA2, post: 1106710, member: 212630"] No test has 100% sensitivity or specificity. A1C has a n error rate of +/- 0.5% or 5mmol/Mol. OGTT are also very variable and much more dependant on subject and operator adhering to the protocol. 3 days of adequate CHO intake, correct fasting period and correct timing of venesection. Even when carried out correctly it, has significant variability. Another rather bizarre aspect of GTTs is that we give the same (huge) dose of glucose to a 55kg woman as we would to a 110kg male.This test is an anachronism. I very rarely order n OGTT for patients other than for gestational diabetes, for very specific reasons. Dysglycemia is part of a continuum. Lower glucose is desirable, and attempts to achieve lower BGLs are to be encouraged , as long as the risk benefit equation falls on the right side. It's easy to get fixated on the numbers. They are a very important and useful barometers that help track progress and quantify risk, but it's easy to be distracted by the minutiae. [/QUOTE]
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